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10.1016/j.celrep.2015.05.027 http://scihub22266oqcxt.onion/10.1016/j.celrep.2015.05.027 C4481182!4481182!26074073     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26074073&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Rep 2015 ; 11 (11): 1809-21 Nephropedia Template TP {{tp|p=26074073|t=2015. A CDC20-APC/SOX2 Signaling Axis Regulates Human Glioblastoma Stem-Like Cells |pdf=|usr=}}{{26074073}} gab.com Text A CDC20-APC/SOX2 Signaling Axis Regulates Human Glioblastoma Stem-Like Cells JO: Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=26074073 #FOAvip Glioblastoma harbors a dynamic subpopulation of glioblastoma stem-like cells (GSCs) that can propagate tumors in vivo and is resistant to standard chemoradiation. Identification of the cell-intrinsic mechanisms governing this clinically important cell state may lead to the discovery of novel therapeutic strategies for this challenging malignancy. Here, we demonstrate that the mitotic E3 ubiquitin ligase CDC20-Anaphase-Promoting Complex (CDC20-APC) drives invasiveness and self-renewal in patient tumor-derived GSCs. Moreover, CDC20 knockdown inhibited and CDC20 overexpression increased the ability of human GSCs to generate brain tumors in an orthotopic xenograft model in vivo. CDC20-APC control of GSC invasion and self-renewal operates through pluripotency-related transcription factor SOX2. Our results identify a CDC20-APC/SOX2 signaling axis that controls key biological properties of GSCs, with implications for CDC20-APC-targeted strategies in the treatment of glioblastoma. Twit Text FOAVip A CDC20-APC/SOX2 Signaling Axis Regulates Human Glioblastoma Stem-Like Cells ????Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=26074073 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26074073 #FOAvip English Wikipedia <ref>{{Cite pmid|26074073}}</ref> A CDC20-APC/SOX2 Signaling Axis Regulates Human Glioblastoma Stem-Like Cells #MMPMID26074073 Mao DD; Gujar AD; Mahlokozera T; Chen I; Pan Y; Luo J; Brost T; Thompson EA; Turski A; Leuthardt EC; Dunn GP; Chicoine MR; Rich KM; Dowling JL; Zipfel GJ; Dacey RG; Achilefu S; Tran DD; Yano H; Kim AH Cell Rep 2015[Jun]; 11 (11): 1809-21 PMID26074073show ga Glioblastoma harbors a dynamic subpopulation of glioblastoma stem-like cells (GSCs) that can propagate tumors in vivo and is resistant to standard chemoradiation. Identification of the cell-intrinsic mechanisms governing this clinically important cell state may lead to the discovery of novel therapeutic strategies for this challenging malignancy. Here, we demonstrate that the mitotic E3 ubiquitin ligase CDC20-Anaphase-Promoting Complex (CDC20-APC) drives invasiveness and self-renewal in patient tumor-derived GSCs. Moreover, CDC20 knockdown inhibited and CDC20 overexpression increased the ability of human GSCs to generate brain tumors in an orthotopic xenograft model in vivo. CDC20-APC control of GSC invasion and self-renewal operates through pluripotency-related transcription factor SOX2. Our results identify a CDC20-APC/SOX2 signaling axis that controls key biological properties of GSCs, with implications for CDC20-APC-targeted strategies in the treatment of glioblastoma. äA CDC20-APC/SOX2 Signaling Axis Regulates Human Glioblastoma Stem-Like(epmc).pdf DeepDyve Pubget Overpricing