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10.1016/j.celrep.2015.05.023 http://scihub22266oqcxt.onion/10.1016/j.celrep.2015.05.023 C4481133!4481133!26074074     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Rep 2015 ; 11 (11): 1686-93 Nephropedia Template TP {{tp|p=26074074|t=2015. Iron toxicity in the retina requires Alu RNA and the NLRP3 inflammasome |pdf=|usr=}}{{26074074}} gab.com Text Iron toxicity in the retina requires Alu RNA and the NLRP3 inflammasome JO: Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=26074074 #FOAvip Excess iron induces tissue damage and is implicated in age-related macular degeneration (AMD). Iron toxicity is widely attributed to hydroxyl radical formation through Fenton's reaction. We report that excess iron, but not other Fenton catalytic metals, induces activation of the NLRP3 inflammasome, a pathway also implicated in AMD. Additionally, iron-induced degeneration of the retinal pigmented epithelium (RPE) is suppressed in mice lacking inflammasome components Caspase-1/11 or Nlrp3 or by inhibition of Caspase-1. Iron overload increases abundance of RNAs transcribed from short interspersed nuclear elements (SINEs): Alu RNAs and the rodent equivalent B1 and B2 RNAs, which are inflammasome agonists. Targeting Alu or B2 RNA prevents iron-induced inflammasome activation and RPE degeneration. Iron-induced SINE RNA accumulation is due to suppression of DICER1 via sequestration of the co-factor poly(C)-binding protein 2 (PCBP2). These findings reveal an unexpected mechanism of iron toxicity, with implications for AMD and neurodegenerative diseases associated with excess iron. Twit Text FOAVip Iron toxicity in the retina requires Alu RNA and the NLRP3 inflammasome ????Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=26074074 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26074074 #FOAvip English Wikipedia <ref>{{Cite pmid|26074074}}</ref> Iron toxicity in the retina requires Alu RNA and the NLRP3 inflammasome #MMPMID26074074 Gelfand BD; Wright CB; Kim Y; Yasuma T; Yasuma R; Li S; Fowler BJ; Bastos-Carvalho A; Kerur N; Uittenbogaard A; Han YS; Lou D; Kleinman ME; McDonald WH; Núñez G; Georgel P; Dunaief JL; Ambati J Cell Rep 2015[Jun]; 11 (11): 1686-93 PMID26074074show ga Excess iron induces tissue damage and is implicated in age-related macular degeneration (AMD). Iron toxicity is widely attributed to hydroxyl radical formation through Fenton's reaction. We report that excess iron, but not other Fenton catalytic metals, induces activation of the NLRP3 inflammasome, a pathway also implicated in AMD. Additionally, iron-induced degeneration of the retinal pigmented epithelium (RPE) is suppressed in mice lacking inflammasome components Caspase-1/11 or Nlrp3 or by inhibition of Caspase-1. Iron overload increases abundance of RNAs transcribed from short interspersed nuclear elements (SINEs): Alu RNAs and the rodent equivalent B1 and B2 RNAs, which are inflammasome agonists. Targeting Alu or B2 RNA prevents iron-induced inflammasome activation and RPE degeneration. Iron-induced SINE RNA accumulation is due to suppression of DICER1 via sequestration of the co-factor poly(C)-binding protein 2 (PCBP2). These findings reveal an unexpected mechanism of iron toxicity, with implications for AMD and neurodegenerative diseases associated with excess iron. äIron toxicity in the retina requires Alu RNA and the NLRP3 inflammasom(epmc).pdf DeepDyve Pubget Overpricing