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http://scihub22266oqcxt.onion/ C4480757!4480757!25823657     free     free     free       Oncotarget 2015 ; 6 (10): 8353-65 Nephropedia Template TP {{tp|p=25823657|t=2015. HOTAIR is a therapeutic target in glioblastoma |pdf=|usr=}}{{25823657}} gab.com Text HOTAIR is a therapeutic target in glioblastoma JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=25823657 #FOAvip HOTAIR is a negative prognostic factor and is overexpressed in multiple human cancers including glioblastoma multiform (GBM). Survival analysis of Chinese Glioma Genome Atlas (CGGA) patient data indicated that high HOTAIR expression was associated with poor outcome in GBM patients. NLK (Nemo-like kinase), a negative regulator of the ?-catenin pathway, was negatively correlated with HOTAIR expression. When the ?-catenin pathway was inhibited, GBM cells became susceptible to cell cycle arrest and inhibition of invasion. Introduction of the HOTAIR 5? domain in human glioma-derived astrocytoma induced ?-catenin. An intracranial animal model was used to confirm that HOTAIR depletion inhibited GBM cell migration/invasion. In the orthotopic model, HOTAIR was required for GBM formation in vivo. In summary, HOTAIR is a potential therapeutic target in GBM. Twit Text FOAVip HOTAIR is a therapeutic target in glioblastoma ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=25823657 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25823657 #FOAvip English Wikipedia <ref>{{Cite pmid|25823657}}</ref> HOTAIR is a therapeutic target in glioblastoma #MMPMID25823657 Zhou X; Ren Y; Zhang J; Zhang C; Zhang K; Han L; Kong L; Wei J; Chen L; Yang J; Wang Q; Zhang J; Yang Y; Jiang T; Li M; Kang C Oncotarget 2015[Apr]; 6 (10): 8353-65 PMID25823657show ga HOTAIR is a negative prognostic factor and is overexpressed in multiple human cancers including glioblastoma multiform (GBM). Survival analysis of Chinese Glioma Genome Atlas (CGGA) patient data indicated that high HOTAIR expression was associated with poor outcome in GBM patients. NLK (Nemo-like kinase), a negative regulator of the ?-catenin pathway, was negatively correlated with HOTAIR expression. When the ?-catenin pathway was inhibited, GBM cells became susceptible to cell cycle arrest and inhibition of invasion. Introduction of the HOTAIR 5? domain in human glioma-derived astrocytoma induced ?-catenin. An intracranial animal model was used to confirm that HOTAIR depletion inhibited GBM cell migration/invasion. In the orthotopic model, HOTAIR was required for GBM formation in vivo. In summary, HOTAIR is a potential therapeutic target in GBM. äHOTAIR is a therapeutic target in glioblastoma (epmc).pdf DeepDyve Pubget Overpricing