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CD133 initiates tumors, induces epithelial-mesenchymal transition and increases
metastasis in pancreatic cancer
#MMPMID25829252
Nomura A
; Banerjee S
; Chugh R
; Dudeja V
; Yamamoto M
; Vickers SM
; Saluja AK
Oncotarget
2015[Apr]; 6
(10
): 8313-22
PMID25829252
show ga
CD133 has been implicated as a cancer stem cell (CSC) surface marker in several
malignancies including pancreatic cancer. However, the functional role of this
surface glycoprotein in the cancer stem cell remains elusive. In this study, we
determined that CD133 overexpression induced "stemness" properties in MIA-PaCa2
cells along with increased tumorigenicity, tumor progression, and metastasis in
vivo. Additionally, CD133 expression induced epithelial-mesenchymal transition
(EMT) and increased in vitro invasion. EMT induction and increased invasiveness
were mediated by NF-?B activation, as inhibition of NF-?B mitigated these
effects. This study showed that CD133 expression contributes to pancreatic cancer
"stemness," tumorigenicity, EMT induction, invasion, and metastasis.
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