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2015 ; 6
(10
): 8261-70
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Peripheral myeloid-derived suppressor and T regulatory PD-1 positive cells
predict response to neoadjuvant short-course radiotherapy in rectal cancer
patients
#MMPMID25823653
Napolitano M
; D'Alterio C
; Cardone E
; Trotta AM
; Pecori B
; Rega D
; Pace U
; Scala D
; Scognamiglio G
; Tatangelo F
; Cacciapuoti C
; Pacelli R
; Delrio P
; Scala S
Oncotarget
2015[Apr]; 6
(10
): 8261-70
PMID25823653
show ga
Short-course preoperative radiotherapy (SC-RT) followed by total mesorectal
excision (TME) is one therapeutic option for locally advanced rectal cancer
(LARC) patients. Since radio-induced DNA damage may affect tumor immunogenicity,
Myeloid-derived suppressor cells (MDSCs) and T regulatory cells (Tregs) were
evaluated in 13 patients undergoing SC-RT and TME for LARC. Peripheral
Granulocytic-MDSCs (G-MDSC) [LIN-/HLA-DR-/CD11b+/CD14-/CD15+/CD33+], Monocytic
(M-MDSC) [CD14+/HLA-DR-/lowCD11b+/CD33+] and Tregs [CD4+/CD25hi+/FOXP3+-
CTLA-4/PD1] basal value was significantly higher in LARC patients compared to
healthy donors (HD). Peripheral MDSC and Tregs were evaluated at time 0 (T0),
after 2 and 5 weeks (T2-T5) from radiotherapy; before surgery (T8) and 6-12
months after surgery (T9, T10). G-MDSC decreased at T5 and further at T8 while
M-MDSC cells decreased at T5; Tregs reached the lowest value at T5. LARC poor
responder patients displayed a major decrease in M-MDSC after SC-RT and an
increase of Treg-PD-1. In this pilot study MDSCs and Tregs decrease during the
SC-RT treatment could represent a biomarker of response in LARC patients. Further
studies are needed to confirm that the deepest M-MDSC reduction and increase in
Treg-PD1 cells within 5-8 weeks from the beginning of treatment could
discriminate LARC patients poor responding to SC-RT.