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10.18632/oncotarget.3014

http://scihub22266oqcxt.onion/10.18632/oncotarget.3014
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suck abstract from ncbi


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pmid25823653
      Oncotarget 2015 ; 6 (10 ): 8261-70
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  • Peripheral myeloid-derived suppressor and T regulatory PD-1 positive cells predict response to neoadjuvant short-course radiotherapy in rectal cancer patients #MMPMID25823653
  • Napolitano M ; D'Alterio C ; Cardone E ; Trotta AM ; Pecori B ; Rega D ; Pace U ; Scala D ; Scognamiglio G ; Tatangelo F ; Cacciapuoti C ; Pacelli R ; Delrio P ; Scala S
  • Oncotarget 2015[Apr]; 6 (10 ): 8261-70 PMID25823653 show ga
  • Short-course preoperative radiotherapy (SC-RT) followed by total mesorectal excision (TME) is one therapeutic option for locally advanced rectal cancer (LARC) patients. Since radio-induced DNA damage may affect tumor immunogenicity, Myeloid-derived suppressor cells (MDSCs) and T regulatory cells (Tregs) were evaluated in 13 patients undergoing SC-RT and TME for LARC. Peripheral Granulocytic-MDSCs (G-MDSC) [LIN-/HLA-DR-/CD11b+/CD14-/CD15+/CD33+], Monocytic (M-MDSC) [CD14+/HLA-DR-/lowCD11b+/CD33+] and Tregs [CD4+/CD25hi+/FOXP3+- CTLA-4/PD1] basal value was significantly higher in LARC patients compared to healthy donors (HD). Peripheral MDSC and Tregs were evaluated at time 0 (T0), after 2 and 5 weeks (T2-T5) from radiotherapy; before surgery (T8) and 6-12 months after surgery (T9, T10). G-MDSC decreased at T5 and further at T8 while M-MDSC cells decreased at T5; Tregs reached the lowest value at T5. LARC poor responder patients displayed a major decrease in M-MDSC after SC-RT and an increase of Treg-PD-1. In this pilot study MDSCs and Tregs decrease during the SC-RT treatment could represent a biomarker of response in LARC patients. Further studies are needed to confirm that the deepest M-MDSC reduction and increase in Treg-PD1 cells within 5-8 weeks from the beginning of treatment could discriminate LARC patients poor responding to SC-RT.
  • |Adult [MESH]
  • |Aged [MESH]
  • |Aged, 80 and over [MESH]
  • |Female [MESH]
  • |Humans [MESH]
  • |Male [MESH]
  • |Middle Aged [MESH]
  • |Myeloid Cells/*immunology/radiation effects [MESH]
  • |Neoadjuvant Therapy [MESH]
  • |Programmed Cell Death 1 Receptor/*immunology [MESH]
  • |Radiotherapy, Adjuvant [MESH]
  • |Rectal Neoplasms/*immunology/pathology/*radiotherapy [MESH]


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