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10.18632/oncotarget.3505 http://scihub22266oqcxt.onion/10.18632/oncotarget.3505 C4480730!4480730 !25797266     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25797266 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Oncotarget 2015 ; 6 (10 ): 7992-8006 Nephropedia Template TP {{tp|p=25797266 |t=2015. Tetrandrine induces autophagy and differentiation by activating ROS and Notch1 signaling in leukemia cells |pdf=|usr=}}{{25797266 }} gab.com Text Tetrandrine induces autophagy and differentiation by activating ROS and Notch1 signaling in leukemia cells JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=25797266 #FOAvip All-trans retinoic acid (ATRA) is a differentiating agent for the treatment of acute promyelocytic leukemia (APL). However, the therapeutic efficacy of ATRA has limitations. Tetrandrine is a traditional Chinese medicinal herb extract with antitumor effects. In this study, we investigated the effects of tetrandrine on human PML-RAR?-positive acute promyelocytic leukemia cells. Tetrandrine inhibited tumors in vivo. It induced autophagy and differentiation by triggering ROS generation and activating Notch1 signaling. Tetrandrine induced autophagy and differentiation in M5 type patient primary leukemia cells. The in vivo results indicated that low concentrations of tetrandrine inhibited leukemia cells proliferation and induced autophagy and then facilitated their differentiation, by activating ROS and Notch1 signaling. We suggest that tetrandrine is a potential agent for the treatment of APL by inducing differentiation of leukemia cells. Twit Text FOAVip Tetrandrine induces autophagy and differentiation by activating ROS and Notch1 signaling in leukemia cells ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=25797266 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25797266 #FOAvip English Wikipedia <ref>{{Cite pmid|25797266 }}</ref> Tetrandrine induces autophagy and differentiation by activating ROS and Notch1 signaling in leukemia cells #MMPMID25797266 Liu T ; Men Q ; Wu G ; Yu C ; Huang Z ; Liu X ; Li W Oncotarget 2015[Apr]; 6 (10 ): 7992-8006 PMID25797266 show ga All-trans retinoic acid (ATRA) is a differentiating agent for the treatment of acute promyelocytic leukemia (APL). However, the therapeutic efficacy of ATRA has limitations. Tetrandrine is a traditional Chinese medicinal herb extract with antitumor effects. In this study, we investigated the effects of tetrandrine on human PML-RAR?-positive acute promyelocytic leukemia cells. Tetrandrine inhibited tumors in vivo. It induced autophagy and differentiation by triggering ROS generation and activating Notch1 signaling. Tetrandrine induced autophagy and differentiation in M5 type patient primary leukemia cells. The in vivo results indicated that low concentrations of tetrandrine inhibited leukemia cells proliferation and induced autophagy and then facilitated their differentiation, by activating ROS and Notch1 signaling. We suggest that tetrandrine is a potential agent for the treatment of APL by inducing differentiation of leukemia cells. |Animals [MESH] |Antineoplastic Agents/*pharmacology [MESH] |Autophagy/drug effects [MESH] |Benzylisoquinolines/*pharmacology [MESH] |Cell Differentiation/drug effects [MESH] |Drugs, Chinese Herbal/pharmacology [MESH] |Humans [MESH] |Leukemia, Promyelocytic, Acute/*drug therapy/metabolism/pathology [MESH] |Male [MESH] |Mice [MESH] |Mice, Inbred BALB C [MESH] |Mice, Nude [MESH] |Reactive Oxygen Species/metabolism [MESH] |Receptor, Notch1/*metabolism [MESH] |Signal Transduction [MESH]Tetrandrine induces autophagy and differentiation by activating ROS an(epmc).pdf DeepDyve Pubget Overpricing