Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26136838
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Therap+Adv+Gastroenterol
2015 ; 8
(4
): 206-20
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Chronic opioid induced constipation in patients with nonmalignant pain:
challenges and opportunities
#MMPMID26136838
Nelson AD
; Camilleri M
Therap Adv Gastroenterol
2015[Jul]; 8
(4
): 206-20
PMID26136838
show ga
With the recent introduction and approval of medications directed at the
treatment of opioid induced constipation (OIC) in patients with nonmalignant
pain, there is increased interest and understanding of the unmet need and
opportunities to enhance patient management. The high incidence of OIC is
associated with rapid increase of narcotic analgesic prescriptions for
nonmalignant chronic pain. This review addresses briefly the mechanisms of action
of opioids that lead to OIC, the differential tolerance of gastrointestinal
organs to the effects of opioids, the size and scope of the problem, the
definition and outcome measures for OIC, current differential diagnosis and
management algorithms, and the pharmacology and efficacy of treatments for OIC in
patients with nonmalignant pain.