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10.1177/1756283X15578607

http://scihub22266oqcxt.onion/10.1177/1756283X15578607
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C4480570!4480570!26136834
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suck abstract from ncbi


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pmid26136834      Therap+Adv+Gastroenterol 2015 ; 8 (4): 168-75
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  • Specialized enteral nutrition therapy in Crohn?s disease patients on maintenance infliximab therapy: a meta-analysis #MMPMID26136834
  • Nguyen DL; Palmer LB; Nguyen ET; McClave SA; Martindale RG; Bechtold ML
  • Therap Adv Gastroenterol 2015[Jul]; 8 (4): 168-75 PMID26136834show ga
  • Objectives:: Many patients with Crohn?s disease on infliximab maintenance therapy have recurrent symptoms despite an initial clinical response. Therefore, concomitant therapies have been studied. We conducted a meta-analysis to assess the effect of specialized enteral nutrition therapy with infliximab versus infliximab monotherapy in patients with Crohn?s disease. Methods:: A comprehensive search of multiple databases was performed. All studies of adult patients with Crohn?s disease comparing specialized enteral nutrition therapy (elemental or polymeric diet with low-fat or regular diet) with infliximab versus infliximab monotherapy without dietary restrictions were included. Meta-analysis was performed using the Mantel?Haenszel (fixed effect) model with odds ratio (OR) to assess for clinical remission. Results:: Four studies (n = 342) met inclusion criteria. Specialized enteral nutrition therapy with infliximab resulted in 109 of 157 (69.4%) patients reaching clinical remission compared with 84 of 185 (45.4%) with infliximab monotherapy [OR 2.73; 95% confidence interval (CI): 1.73?4.31, p < 0.01]. Similarly, 79 of 106 (74.5%) patients receiving enteral nutrition therapy and infliximab remained in clinical remission after one year compared with 62 of 126 (49.2%) patients receiving infliximab monotherapy (OR 2.93; 95% CI: 1.66?5.17, p < 0.01). No publication bias or heterogeneity was noted for either outcome. Conclusions:: The use of specialized enteral nutrition therapy in combination with infliximab appears to be more effective at inducing and maintaining clinical remission among patients with Crohn?s disease than infliximab monotherapy.
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