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10.1038/ncomms8386 http://scihub22266oqcxt.onion/10.1038/ncomms8386 C4480344!4480344!26077348     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Commun 2015 ; 6 (ä): 7386 Nephropedia Template TP {{tp|p=26077348|t=2015. The Matricellular Protein CCN1 Mediates Neutrophil Efferocytosis in Cutaneous Wound Healing |pdf=|usr=}}{{26077348}} gab.com Text The Matricellular Protein CCN1 Mediates Neutrophil Efferocytosis in Cutaneous Wound Healing JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=26077348 #FOAvip Neutrophil infiltration constitutes the first step in wound healing, although their timely clearance by macrophage engulfment, or efferocytosis, is critical for efficient tissue repair. However, the specific mechanism for neutrophil clearance in wound healing remains undefined. Here we uncover a key role for CCN1 in neutrophil efferocytosis by acting as a bridging molecule that binds phosphatidylserine, the ?eat-me? signal on apoptotic cells, and integrins ?v?3/?v?5 in macrophages to trigger efferocytosis. Both knockin mice expressing a mutant CCN1 that is unable to bind ?v?3/?v?5 and mice with Ccn1 knockdown are defective in neutrophil efferocytosis, resulting in exuberant neutrophil accumulation and delayed healing. Treatment of wounds with CCN1 accelerates neutrophil clearance in both Ccn1 knockin mice and diabetic Leprdb/db mice, which suffer from neutrophil persistence and impaired healing. These findings establish CCN1 as a critical opsonin in skin injury and suggest a therapeutic potential for CCN1 in certain types of non-healing wounds. Twit Text FOAVip The Matricellular Protein CCN1 Mediates Neutrophil Efferocytosis in Cutaneous Wound Healing ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=26077348 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26077348 #FOAvip English Wikipedia <ref>{{Cite pmid|26077348}}</ref> The Matricellular Protein CCN1 Mediates Neutrophil Efferocytosis in Cutaneous Wound Healing #MMPMID26077348 Jun JI; Kim KH; Lau LF Nat Commun 2015[]; 6 (ä): 7386 PMID26077348show ga Neutrophil infiltration constitutes the first step in wound healing, although their timely clearance by macrophage engulfment, or efferocytosis, is critical for efficient tissue repair. However, the specific mechanism for neutrophil clearance in wound healing remains undefined. Here we uncover a key role for CCN1 in neutrophil efferocytosis by acting as a bridging molecule that binds phosphatidylserine, the ?eat-me? signal on apoptotic cells, and integrins ?v?3/?v?5 in macrophages to trigger efferocytosis. Both knockin mice expressing a mutant CCN1 that is unable to bind ?v?3/?v?5 and mice with Ccn1 knockdown are defective in neutrophil efferocytosis, resulting in exuberant neutrophil accumulation and delayed healing. Treatment of wounds with CCN1 accelerates neutrophil clearance in both Ccn1 knockin mice and diabetic Leprdb/db mice, which suffer from neutrophil persistence and impaired healing. These findings establish CCN1 as a critical opsonin in skin injury and suggest a therapeutic potential for CCN1 in certain types of non-healing wounds. äThe Matricellular Protein CCN1 Mediates Neutrophil Efferocytosis in Cu(epmc).pdf DeepDyve Pubget Overpricing