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10.1016/j.coi.2012.12.007

http://scihub22266oqcxt.onion/10.1016/j.coi.2012.12.007
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C4480265!4480265!23332826
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suck abstract from ncbi


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pmid23332826      Curr+Opin+Immunol 2013 ; 25 (1): 46-52
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  • Sensing of cell death by myeloid C-type lectin receptors #MMPMID23332826
  • Sancho D; Reis e Sousa C
  • Curr Opin Immunol 2013[Feb]; 25 (1): 46-52 PMID23332826show ga
  • Molecules associated with dead or dying cells can be detected by receptors on macrophages and dendritic cells. Signals from these receptors impact myeloid cell function and play a role in determining whether death is silent or proinflammatory, tolerogenic or immunogenic. Prominent among myeloid receptors detecting dead cells are C-type lectin receptors (CLRs). Signals from these receptors variably induce endocytosis of cell corpses, corpse degradation, retrieval of dead cell-associated antigens and/or modulation of immune responses. The sensing of tissue damage by myeloid CLRs complements detection of pathogens in immunity and represents an ancient response aimed at restoring tissue homeostasis.
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