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2015 ; 56
(4
): 968-75
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The Clinical Courses of Patients with Congenital Cystic Adenomatoid Malformation
Complicated by Pneumonia
#MMPMID26069118
Jhun BW
; Kim SJ
; Kim K
; Kim S
; Lee JE
Yonsei Med J
2015[Jul]; 56
(4
): 968-75
PMID26069118
show ga
PURPOSE: We evaluated the clinical characteristics and courses of patients with
congenital cystic adenomatoid malformation (CCAM) complicated by pneumonia.
MATERIALS AND METHODS: We retrospectively reviewed the records of 19 adult
patients with surgically confirmed CCAM between March 2005 and July 2013.
RESULTS: Eighteen of nineteen patients presented with acute pneumonia symptoms
and signs, and inflammatory markers were elevated. On chest computed tomography,
all 18 patients had parenchymal infiltration around cystic lesions, 17 (94%) had
an air-fluid level, and 2 (11%) had pleural effusion. After antibiotics treatment
for a median of 22 days prior to surgery, all acute pneumonia symptoms and signs
disappeared in 17 (94%) patients at a median of 10 days. Improvements and
normalization of inflammatory marker levels, occurred in 17 (94%) and 9 (50%)
patients at medians of 8 and 17 days, respectively. Radiological improvement was
evident in 11 (61%) patients, at a median of 18 days, of these patients, partial
radiological improvement occurred in 10 (56%) and complete radiological
resolution in only 1 (6%). One patient (6%) did not improve in terms of clinical,
laboratory, or radiological findings despite antibiotic treatment for 13 days.
Consequently, after 17 (94%) elective and 1 (6%) emergency surgeries, all
patients improved without development of complications. CONCLUSION: We described
the clinical characteristics and courses of patients with CCAM complicated by
pneumonia, and showed that surgery may be performed safely after
clinicolaboratory improvement is attained upon antibiotic treatment, even in the
absence of complete radiological resolution.
|Adult
[MESH]
|Cystic Adenomatoid Malformation of Lung, Congenital/*diagnosis/*surgery/therapy
[MESH]