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10.3389/fimmu.2015.00312 http://scihub22266oqcxt.onion/10.3389/fimmu.2015.00312 C4479820!4479820!26161082     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Front+Immunol 2015 ; 6 (ä): ä Nephropedia Template TP {{tp|p=26161082|t=2015. CD1d Expression and Invariant NKT Cell Responses in Herpesvirus Infections |pdf=|usr=}}{{26161082}} gab.com Text CD1d Expression and Invariant NKT Cell Responses in Herpesvirus Infections JO: Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=26161082 #FOAvip Invariant natural killer T (iNKT) cells are a highly conserved subset of unconventional T lymphocytes that express a canonical, semi-invariant T cell receptor and surface markers shared with the natural killer cell lineage. iNKT cells recognize exogenous and endogenous glycolipid antigens restricted by non-polymorphic CD1d molecules, and are highly responsive to the prototypical agonist, ?-galactosylceramide. Upon activation, iNKT cells rapidly coordinate signaling between innate and adaptive immune cells through the secretion of proinflammatory cytokines, leading to the maturation of antigen-presenting cells, and expansion of antigen-specific CD4+ and CD8+ T cells. Because of their potent immunoregulatory properties, iNKT cells have been extensively studied and are known to play a pivotal role in mediating immune responses against microbial pathogens including viruses. Here, we review evidence that herpesviruses manipulate CD1d expression to escape iNKT cell surveillance and establish lifelong latency in humans. Collectively, published findings suggest that iNKT cells play critical roles in anti-herpesvirus immune responses and could be harnessed therapeutically to limit viral infection and viral-associated disease. Twit Text FOAVip CD1d Expression and Invariant NKT Cell Responses in Herpesvirus Infections ????Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=26161082 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26161082 #FOAvip English Wikipedia <ref>{{Cite pmid|26161082}}</ref> CD1d Expression and Invariant NKT Cell Responses in Herpesvirus Infections #MMPMID26161082 Chung BK; Priatel JJ; Tan R Front Immunol 2015[]; 6 (ä): ä PMID26161082show ga Invariant natural killer T (iNKT) cells are a highly conserved subset of unconventional T lymphocytes that express a canonical, semi-invariant T cell receptor and surface markers shared with the natural killer cell lineage. iNKT cells recognize exogenous and endogenous glycolipid antigens restricted by non-polymorphic CD1d molecules, and are highly responsive to the prototypical agonist, ?-galactosylceramide. Upon activation, iNKT cells rapidly coordinate signaling between innate and adaptive immune cells through the secretion of proinflammatory cytokines, leading to the maturation of antigen-presenting cells, and expansion of antigen-specific CD4+ and CD8+ T cells. Because of their potent immunoregulatory properties, iNKT cells have been extensively studied and are known to play a pivotal role in mediating immune responses against microbial pathogens including viruses. Here, we review evidence that herpesviruses manipulate CD1d expression to escape iNKT cell surveillance and establish lifelong latency in humans. Collectively, published findings suggest that iNKT cells play critical roles in anti-herpesvirus immune responses and could be harnessed therapeutically to limit viral infection and viral-associated disease. äCD1d Expression and Invariant NKT Cell Responses in Herpesvirus Infect(epmc).pdf DeepDyve Pubget Overpricing