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10.1038/ncomms8476 http://scihub22266oqcxt.onion/10.1038/ncomms8476 C4479597!4479597 !26101153     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26101153 &cmd=llinks): Failed to open stream: HTTP request failed! 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Zic1 controls placode progenitor formation non-cell autonomously by regulating retinoic acid production and transport |pdf=|usr=}}{{26101153 }} gab.com Text Zic1 controls placode progenitor formation non-cell autonomously by regulating retinoic acid production and transport JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=26101153 #FOAvip All cranial placode progenitors arise from a common precursor field anterior to the neural plate, the pre-placodal region (PPR). We showed that transcription factor Zic1, expressed at the anterior neural plate, is necessary and sufficient to promote placode fate. Here we reveal the non-cell autonomous activity of Zic1 and implicate retinoic acid (RA) signalling as a key player in cranial placode progenitor specification. In a screen for genes activated by Zic1, we identify several factors involved in RA metabolism and function. Among them we show that retinaldehyde dehydrogenase 2 (RALDH2) and lipocalin-type prostaglandin D2 synthase (LPGDS), which, respectively, regulate the synthesis and transport of RA, directly participate in the establishment of the PPR. We propose that RALDH2 and LPGDS induction by Zic1 at the anterior neural plate allows for the localized production and transport of RA, which in turn activates a cranial placode developmental programme in neighbouring cells. Twit Text FOAVip Zic1 controls placode progenitor formation non-cell autonomously by regulating retinoic acid production and transport ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=26101153 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26101153 #FOAvip English Wikipedia <ref>{{Cite pmid|26101153 }}</ref> Zic1 controls placode progenitor formation non-cell autonomously by regulating retinoic acid production and transport #MMPMID26101153 Jaurena MB ; Juraver-Geslin H ; Devotta A ; Saint-Jeannet JP Nat Commun 2015[Jun]; 6 (ä): 7476 PMID26101153 show ga All cranial placode progenitors arise from a common precursor field anterior to the neural plate, the pre-placodal region (PPR). We showed that transcription factor Zic1, expressed at the anterior neural plate, is necessary and sufficient to promote placode fate. Here we reveal the non-cell autonomous activity of Zic1 and implicate retinoic acid (RA) signalling as a key player in cranial placode progenitor specification. In a screen for genes activated by Zic1, we identify several factors involved in RA metabolism and function. Among them we show that retinaldehyde dehydrogenase 2 (RALDH2) and lipocalin-type prostaglandin D2 synthase (LPGDS), which, respectively, regulate the synthesis and transport of RA, directly participate in the establishment of the PPR. We propose that RALDH2 and LPGDS induction by Zic1 at the anterior neural plate allows for the localized production and transport of RA, which in turn activates a cranial placode developmental programme in neighbouring cells. |*Gene Expression Regulation, Developmental [MESH] |Aldehyde Dehydrogenase 1 Family [MESH] |Aldehyde Oxidase/genetics/metabolism [MESH] |Animals [MESH] |Ectoderm/*embryology/metabolism [MESH] |Embryo, Nonmammalian [MESH] |In Situ Hybridization [MESH] |Intramolecular Oxidoreductases/genetics/metabolism [MESH] |Lipocalins/genetics/metabolism [MESH] |Neural Plate/embryology/metabolism [MESH] |Neurogenesis/*genetics [MESH] |RNA, Messenger/*metabolism [MESH] |Real-Time Polymerase Chain Reaction [MESH] |Retinal Dehydrogenase [MESH] |Signal Transduction [MESH] |Stem Cells/*metabolism [MESH] |Transcription Factors/*genetics/metabolism [MESH] |Tretinoin/*metabolism [MESH] |Xenopus Proteins/*genetics/metabolism [MESH]Zic1 controls placode progenitor formation non-cell autonomously by re(epmc).pdf DeepDyve Pubget Overpricing