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2014 ; 23
(4
): 120-125
Nephropedia Template TP
gab.com Text
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English Wikipedia
Mould allergens: Where do we stand with molecular allergy diagnostics?: Part 13
of the series Molecular Allergology
#MMPMID26120524
Kespohl S
; Raulf M
Allergo J Int
2014[]; 23
(4
): 120-125
PMID26120524
show ga
The official WHO/IUIS database (www.allergen.org) currently lists 77 mould
allergens from a variety of protein families. To date, only eight recombinant
single allergens from three mould species are available for molecular allergy
diagnosis of mould sensitization. These include rAlt a 1, the major allergen in
Alternaria alternata-sensitized individuals, and enolase rAlt a 6 with it
potential cross-reactivity to mould, food and natural latex allergens. rAsp f 1,
2, 3, 4 and 6 from Aspergillus fumigatus are available for diagnostic purposes;
specific IgE to rAsp f 2, 4 and 6 is often positive in allergic bronchopulmonary
aspergillosis (ABPA). The dehydrogenase rCla h 8 is considered a major allergen
of Cladosporium herbarum with possible cross-reactivity to other dehydrogenase
allergens. The narrow range of commercially available individual mould allergens
should be expanded to include marker allergens typical for mould (e.g., serine
proteases). In addition, standardization of total extracts needs to be improved
in the future to guarantee valid mould products with defined allergen content for
diagnostic and therapeutic purposes.