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2014 ; 23
(1
): 1-16
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Food allergies resulting from immunological cross-reactivity with inhalant
allergens: Guidelines from the German Society for Allergology and Clinical
Immunology (DGAKI), the German Dermatology Society (DDG), the Association of
German Allergologists (AeDA) and the Society for Pediatric Allergology and
Environmental Medicine (GPA)
#MMPMID26120513
Worm M
; Jappe U
; Kleine-Tebbe J
; Schäfer C
; Reese I
; Saloga J
; Treudler R
; Zuberbier T
; Waßmann A
; Fuchs T
; Dölle S
; Raithel M
; Ballmer-Weber B
; Niggemann B
; Werfel T
Allergo J Int
2014[]; 23
(1
): 1-16
PMID26120513
show ga
A large proportion of immunoglobulin E (IgE)-mediated food allergies in older
children, adolescents and adults are caused by cross-reactive allergenic
structures. Primary sensitization is most commonly to inhalant allergens (e.g.
Bet v 1, the major birch pollen allergen). IgE can be activated by various
cross-reactive allergens and lead to a variety of clinical manifestations. In
general, local and mild - in rare cases also severe and systemic - reactions
occur directly after consumption of the food containing the cross-reactive
allergen (e. g. plant-derived foods containing proteins of the Bet v 1 family).
In clinical practice, sensitization to the primary responsible inhalant and/or
food allergen can be detected by skin prick tests and/or in vitro detection of
specific IgE. Component-based diagnostic methods can support clinical diagnosis.
For individual allergens, these methods may be helpful to estimate the risk of
systemic reactions. Confirmation of sensitization by oral provocation testing is
important particulary in the case of unclear case history. New, as yet
unrecognized allergens can also cause cross-reactions. The therapeutic potential
of specific immunotherapy (SIT) with inhalant allergens and their effect on
pollen-associated food allergies is currently unclear: results vary and
placebo-controlled trials will be necessary in the future. Pollen allergies are
very common. Altogether allergic sensitization to pollen and cross-reactive food
allergens are very common in our latitudes. The actual relevance has to be
assessed on an individual basis using the clinical information. Cite this as Worm
M, Jappe U, Kleine-Tebbe J, Schäfer C, Reese I, Saloga J, Treudler R, Zuberbier
T, Wassmann A, Fuchs T, Dölle S, Raithel M, Ballmer-Weber B, Niggemann B, Werfel
T. Food allergies resulting from immunological cross-reactivity with inhalant
allergens. Allergo J Int 2014; 23: 1-16 DOI 10.1007/s40629-014-0004-6.