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10.1161/CIRCRESAHA.113.301811 http://scihub22266oqcxt.onion/10.1161/CIRCRESAHA.113.301811 C4479408!4479408 !24014829     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\24014829 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Circ+Res 2013 ; 113 (9 ): 1087-1096 Nephropedia Template TP {{tp|p=24014829 |t=2013. Brain angiotensin-converting enzyme type 2 shedding contributes to the development of neurogenic hypertension |pdf=|usr=}}{{24014829 }} gab.com Text Brain angiotensin-converting enzyme type 2 shedding contributes to the development of neurogenic hypertension JO: Circ Res http://www.kidney.de/pget.php?&tw=1&pmid=24014829 #FOAvip RATIONALE: Overactivity of the brain renin-angiotensin system is a major contributor to neurogenic hypertension. Although overexpression of angiotensin-converting enzyme type 2 (ACE2) has been shown to be beneficial in reducing hypertension by transforming angiotensin II into angiotensin-(1-7), several groups have reported decreased brain ACE2 expression and activity during the development of hypertension. OBJECTIVE: We hypothesized that ADAM17-mediated ACE2 shedding results in decreased membrane-bound ACE2 in the brain, thus promoting the development of neurogenic hypertension. METHODS AND RESULTS: To test this hypothesis, we used the deoxycorticosterone acetate-salt model of neurogenic hypertension in nontransgenic and syn-hACE2 mice overexpressing ACE2 in neurons. Deoxycorticosterone acetate-salt treatment in nontransgenic mice led to significant increases in blood pressure, hypothalamic angiotensin II levels, inflammation, impaired baroreflex sensitivity, and autonomic dysfunction, as well as decreased hypothalamic ACE2 activity and expression, although these changes were blunted or prevented in syn-hACE2 mice. In addition, reduction of ACE2 expression and activity in the brain paralleled an increase in ACE2 activity in the cerebrospinal fluid of nontransgenic mice after deoxycorticosterone acetate-salt treatment and were accompanied by enhanced ADAM17 expression and activity in the hypothalamus. Chronic knockdown of ADAM17 in the brain blunted the development of hypertension and restored ACE2 activity and baroreflex function. CONCLUSIONS: Our data provide the first evidence that ADAM17-mediated shedding impairs brain ACE2 compensatory activity, thus contributing to the development of neurogenic hypertension. Twit Text FOAVip Brain angiotensin-converting enzyme type 2 shedding contributes to the development of neurogenic hypertension ????Circ Res http://www.kidney.de/pget.php?&tw=1&pmid=24014829 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24014829 #FOAvip English Wikipedia <ref>{{Cite pmid|24014829 }}</ref> Brain angiotensin-converting enzyme type 2 shedding contributes to the development of neurogenic hypertension #MMPMID24014829 Xia H ; Sriramula S ; Chhabra KH ; Lazartigues E Circ Res 2013[Oct]; 113 (9 ): 1087-1096 PMID24014829 show ga RATIONALE: Overactivity of the brain renin-angiotensin system is a major contributor to neurogenic hypertension. Although overexpression of angiotensin-converting enzyme type 2 (ACE2) has been shown to be beneficial in reducing hypertension by transforming angiotensin II into angiotensin-(1-7), several groups have reported decreased brain ACE2 expression and activity during the development of hypertension. OBJECTIVE: We hypothesized that ADAM17-mediated ACE2 shedding results in decreased membrane-bound ACE2 in the brain, thus promoting the development of neurogenic hypertension. METHODS AND RESULTS: To test this hypothesis, we used the deoxycorticosterone acetate-salt model of neurogenic hypertension in nontransgenic and syn-hACE2 mice overexpressing ACE2 in neurons. Deoxycorticosterone acetate-salt treatment in nontransgenic mice led to significant increases in blood pressure, hypothalamic angiotensin II levels, inflammation, impaired baroreflex sensitivity, and autonomic dysfunction, as well as decreased hypothalamic ACE2 activity and expression, although these changes were blunted or prevented in syn-hACE2 mice. In addition, reduction of ACE2 expression and activity in the brain paralleled an increase in ACE2 activity in the cerebrospinal fluid of nontransgenic mice after deoxycorticosterone acetate-salt treatment and were accompanied by enhanced ADAM17 expression and activity in the hypothalamus. Chronic knockdown of ADAM17 in the brain blunted the development of hypertension and restored ACE2 activity and baroreflex function. CONCLUSIONS: Our data provide the first evidence that ADAM17-mediated shedding impairs brain ACE2 compensatory activity, thus contributing to the development of neurogenic hypertension. |*Blood Pressure/drug effects [MESH] |*Renin-Angiotensin System/drug effects [MESH] |ADAM Proteins/genetics/metabolism [MESH] |ADAM17 Protein [MESH] |Angiotensin II Type 1 Receptor Blockers/pharmacology [MESH] |Angiotensin II/metabolism [MESH] |Angiotensin-Converting Enzyme 2 [MESH] |Animals [MESH] |Antihypertensive Agents/pharmacology [MESH] |Autonomic Nervous System/metabolism/physiopathology [MESH] |Baroreflex [MESH] |Brain/drug effects/*enzymology/physiopathology [MESH] |Desoxycorticosterone Acetate [MESH] |Disease Models, Animal [MESH] |Humans [MESH] |Hypertension/chemically induced/drug therapy/*enzymology/genetics/physiopathology [MESH] |Male [MESH] |Mice [MESH] |Mice, Inbred C57BL [MESH] |Mice, Transgenic [MESH] |Peptidyl-Dipeptidase A/genetics/*metabolism [MESH] |RNA Interference [MESH]Brain angiotensin-converting enzyme type 2 shedding contributes to the(epmc).pdf DeepDyve Pubget Overpricing