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http://scihub22266oqcxt.onion/ C4479305!4479305!20365394     free     free     free       Phys+Rev+E+Stat+Nonlin+Soft+Matter+Phys 2010 ; 81 (1 0 1): 011902 Nephropedia Template TP {{tp|p=20365394|t=2010. Quasispecies theory for finite populations |pdf=|usr=}}{{20365394}} gab.com Text Quasispecies theory for finite populations JO: Phys Rev E Stat Nonlin Soft Matter Phys http://www.kidney.de/pget.php?&tw=1&pmid=20365394 #FOAvip We present stochastic, finite-population formulations of the Crow-Kimura and Eigen models of quasispecies theory, for fitness functions that depend in an arbitrary way on the number of mutations from the wild type. We include back mutations in our description. We show that the fluctuation of the population numbers about the average values are exceedingly large in these physical models of evolution. We further show that horizontal gene transfer reduces by orders of magnitude the fluctuations in the population numbers and reduces the accumulation of deleterious mutations in the finite population due to Muller?s ratchet. Indeed the population sizes needed to converge to the infinite population limit are often larger than those found in nature for smooth fitness functions in the absence of horizontal gene transfer. These analytical results are derived for the steady-state by means of a field-theoretic representation. Numerical results are presented that indicate horizontal gene transfer speeds up the dynamics of evolution as well. Twit Text FOAVip Quasispecies theory for finite populations ????Phys Rev E Stat Nonlin Soft Matter Phys http://www.kidney.de/pget.php?&tw=1&pmid=20365394 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=20365394 #FOAvip English Wikipedia <ref>{{Cite pmid|20365394}}</ref> Quasispecies theory for finite populations #MMPMID20365394 Park JM; Muņoz E; Deem MW Phys Rev E Stat Nonlin Soft Matter Phys 2010[Jan]; 81 (1 0 1): 011902 PMID20365394show ga We present stochastic, finite-population formulations of the Crow-Kimura and Eigen models of quasispecies theory, for fitness functions that depend in an arbitrary way on the number of mutations from the wild type. We include back mutations in our description. We show that the fluctuation of the population numbers about the average values are exceedingly large in these physical models of evolution. We further show that horizontal gene transfer reduces by orders of magnitude the fluctuations in the population numbers and reduces the accumulation of deleterious mutations in the finite population due to Muller?s ratchet. Indeed the population sizes needed to converge to the infinite population limit are often larger than those found in nature for smooth fitness functions in the absence of horizontal gene transfer. These analytical results are derived for the steady-state by means of a field-theoretic representation. Numerical results are presented that indicate horizontal gene transfer speeds up the dynamics of evolution as well. äQuasispecies theory for finite populations (epmc).pdf DeepDyve Pubget Overpricing