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10.1038/ni.2984 http://scihub22266oqcxt.onion/10.1038/ni.2984 C4479254!4479254!25173346     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Immunol 2014 ; 15 (10): 938-46 Nephropedia Template TP {{tp|p=25173346|t=2014. Neutrophils prime a long-lived effector macrophage phenotype that mediates accelerated helminth expulsion |pdf=|usr=}}{{25173346}} gab.com Text Neutrophils prime a long-lived effector macrophage phenotype that mediates accelerated helminth expulsion JO: Nat Immunol http://www.kidney.de/pget.php?&tw=1&pmid=25173346 #FOAvip We examined the role of innate cells in acquired resistance to the natural murine parasitic nematode, Nippostrongylus brasiliensis. Macrophages obtained as late as 45 days after N. brasiliensis inoculation were able to transfer accelerated parasite clearance to naive recipients. Primed macrophages adhered to larvae in vitro and triggered increased mortality of parasites. Neutrophil depletion in primed mice abrogated the protective effects of transferred macrophages and inhibited their in vitro binding to larvae. Neutrophils in parasite-infected mice showed a distinct transcriptional profile and promoted alternatively activated M2 macrophage polarization through secretory factors including IL-13. Differentially activated neutrophils in the context of a type 2 immune response therefore prime a long-lived effector macrophage phenotype that directly mediates rapid nematode damage and clearance. Twit Text FOAVip Neutrophils prime a long-lived effector macrophage phenotype that mediates accelerated helminth expulsion ????Nat Immunol http://www.kidney.de/pget.php?&tw=1&pmid=25173346 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25173346 #FOAvip English Wikipedia <ref>{{Cite pmid|25173346}}</ref> Neutrophils prime a long-lived effector macrophage phenotype that mediates accelerated helminth expulsion #MMPMID25173346 Chen F; Wu W; Millman A; Craft JF; Chen E; Patel N; Boucher JL; Urban JF; Kim CC; Gause WC Nat Immunol 2014[Oct]; 15 (10): 938-46 PMID25173346show ga We examined the role of innate cells in acquired resistance to the natural murine parasitic nematode, Nippostrongylus brasiliensis. Macrophages obtained as late as 45 days after N. brasiliensis inoculation were able to transfer accelerated parasite clearance to naive recipients. Primed macrophages adhered to larvae in vitro and triggered increased mortality of parasites. Neutrophil depletion in primed mice abrogated the protective effects of transferred macrophages and inhibited their in vitro binding to larvae. Neutrophils in parasite-infected mice showed a distinct transcriptional profile and promoted alternatively activated M2 macrophage polarization through secretory factors including IL-13. Differentially activated neutrophils in the context of a type 2 immune response therefore prime a long-lived effector macrophage phenotype that directly mediates rapid nematode damage and clearance. äNeutrophils prime a long-lived effector macrophage phenotype that medi(epmc).pdf DeepDyve Pubget Overpricing