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10.1038/ni.3115 http://scihub22266oqcxt.onion/10.1038/ni.3115 C4479220!4479220!25706746     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Immunol 2015 ; 16 (4): 415-25 Nephropedia Template TP {{tp|p=25706746|t=2015. The RNA-binding protein HuR (Elavl1) is essential for the B cell antibody response |pdf=|usr=}}{{25706746}} gab.com Text The RNA-binding protein HuR (Elavl1) is essential for the B cell antibody response JO: Nat Immunol http://www.kidney.de/pget.php?&tw=1&pmid=25706746 #FOAvip Post-transcriptional regulation of mRNA by the RNA binding protein HuR (Elavl1) is required in B cells for the germinal centre reaction and for the production of class-switched antibodies in response to T-independent antigens. Transcriptome-wide examination of RNA isoforms, abundance and translation in HuR-deficient B cells, together with direct measurements of HuR-RNA interaction, revealed that HuR-dependent mRNA splicing affects hundreds of transcripts including the dihydrolipoamide S-succinyltransferase (Dlst), a subunit of the 2-oxoglutarate dehydrogenase complex (?KGDH). In the absence of HuR, defective mitochondrial metabolism results in high amounts of reactive oxygen species and B cell death. Our study shows how post-transcriptional processes control the balance of energy metabolism required for B cell proliferation and differentiation. Twit Text FOAVip The RNA-binding protein HuR (Elavl1) is essential for the B cell antibody response ????Nat Immunol http://www.kidney.de/pget.php?&tw=1&pmid=25706746 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25706746 #FOAvip English Wikipedia <ref>{{Cite pmid|25706746}}</ref> The RNA-binding protein HuR (Elavl1) is essential for the B cell antibody response #MMPMID25706746 Diaz-Muņoz MD; Bell SE; Fairfax K; Monzon-Casanova E; Cunningham AF; Gonzalez-Porta M; Andrews SR; Bunik VI; Zarnack K; Curk T; Heggermont WA; Heymans S; Gibson GE; Kontoyiannis DL; Ule J; Turner M Nat Immunol 2015[Apr]; 16 (4): 415-25 PMID25706746show ga Post-transcriptional regulation of mRNA by the RNA binding protein HuR (Elavl1) is required in B cells for the germinal centre reaction and for the production of class-switched antibodies in response to T-independent antigens. Transcriptome-wide examination of RNA isoforms, abundance and translation in HuR-deficient B cells, together with direct measurements of HuR-RNA interaction, revealed that HuR-dependent mRNA splicing affects hundreds of transcripts including the dihydrolipoamide S-succinyltransferase (Dlst), a subunit of the 2-oxoglutarate dehydrogenase complex (?KGDH). In the absence of HuR, defective mitochondrial metabolism results in high amounts of reactive oxygen species and B cell death. Our study shows how post-transcriptional processes control the balance of energy metabolism required for B cell proliferation and differentiation. äThe RNA-binding protein HuR (Elavl1) is essential for the B cell antib(epmc).pdf DeepDyve Pubget Overpricing