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10.1007/s40610-015-0002-6

http://scihub22266oqcxt.onion/10.1007/s40610-015-0002-6
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C4479201!4479201!26120554
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suck abstract from ncbi


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pmid26120554      Curr+Mol+Biol+Rep 2015 ; 1 (1): 10-8
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  • Non-Coding RNAs in Transcriptional Regulation: The review for Current Molecular Biology Reports #MMPMID26120554
  • Chen YCA; Aravin AA
  • Curr Mol Biol Rep 2015[Mar]; 1 (1): 10-8 PMID26120554show ga
  • Transcriptional gene silencing guided by small RNAs is a process conserved from protozoa to mammals. Small RNAs loaded into Argonaute family proteins direct repressive histone modifications or DNA cytosine methylation to homologous regions of the genome. Small RNA-mediated transcriptional silencing is required for many biological processes, including repression of transposable elements, maintaining the genome stability/integrity, and epigenetic inheritance of gene expression. Here we will summarize the current knowledge about small RNA biogenesis and mechanisms of transcriptional regulation in plants, Drosophila, C. elegans and mice. Furthermore, a rapidly growing number long non-coding RNAs (lncRNAs) have been implicated as important players in transcription regulation. We will discuss current models for long non-coding RNA-mediated gene regulation.
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