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10.1038/pr.2014.207 http://scihub22266oqcxt.onion/10.1038/pr.2014.207 C4479150!4479150 !25521917     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25521917 &cmd=llinks): Failed to open stream: HTTP request failed! 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Toll-like receptor-4 in human and mouse colonic epithelium is developmentally regulated: a possible role in necrotizing enterocolitis |pdf=|usr=}}{{25521917 }} gab.com Text Toll-like receptor-4 in human and mouse colonic epithelium is developmentally regulated: a possible role in necrotizing enterocolitis JO: Pediatr Res http://www.kidney.de/pget.php?&tw=1&pmid=25521917 #FOAvip BACKGROUND: Necrotizing enterocolitis (NEC) is an immature intestinal condition resulting in devastating intestinal inflammation due to unknown mechanisms. Evidence has suggested that intestinal maturation attenuates the severity of NEC and Toll-like receptor 4 (TLR4) has been suggested to play a critical role in its pathogenesis. We investigated whether maturational effects of TLR4 expression in immature colon might contribute to the development of NEC. METHODS: TLR4 colonocyte expression was detected by immunofluorescence confocal microscopy. Interleukin-6 (IL-6) levels were assayed by an enzyme-linked immunosorbent assay (ELISA). RESULTS: TLR4 expression was high in fetal colonic epithelium in human and mouse, with earlier gestation having a higher surface/cytoplasm distribution. TLR4 remained high in mouse postnatal day 1 but the surface/cytoplasm distribution was reduced. TLR4 decreased in amount and then was expressed in crypts in the mature human and mouse colon. Hydrocortisone (HC) reduced the surface/cytoplasm distribution of TLR4 in human fetal colon. Elevated IL-6 levels in immature colon after lipopolysaccharide were attenuated by HC in human and mouse. CONCLUSION: Expression, localization, and signaling of TLR4 in colonic epithelium may be developmentally regulated. HC may accelerate the TLR developmental pathway change to an adult type, which may account for its impact on TLR4 signaling. Twit Text FOAVip Toll-like receptor-4 in human and mouse colonic epithelium is developmentally regulated: a possible role in necrotizing enterocolitis ????Pediatr Res http://www.kidney.de/pget.php?&tw=1&pmid=25521917 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25521917 #FOAvip English Wikipedia <ref>{{Cite pmid|25521917 }}</ref> Toll-like receptor-4 in human and mouse colonic epithelium is developmentally regulated: a possible role in necrotizing enterocolitis #MMPMID25521917 Meng D ; Zhu W ; Shi HN ; Lu L ; Wijendran V ; Xu W ; Walker WA Pediatr Res 2015[Mar]; 77 (3 ): 416-24 PMID25521917 show ga BACKGROUND: Necrotizing enterocolitis (NEC) is an immature intestinal condition resulting in devastating intestinal inflammation due to unknown mechanisms. Evidence has suggested that intestinal maturation attenuates the severity of NEC and Toll-like receptor 4 (TLR4) has been suggested to play a critical role in its pathogenesis. We investigated whether maturational effects of TLR4 expression in immature colon might contribute to the development of NEC. METHODS: TLR4 colonocyte expression was detected by immunofluorescence confocal microscopy. Interleukin-6 (IL-6) levels were assayed by an enzyme-linked immunosorbent assay (ELISA). RESULTS: TLR4 expression was high in fetal colonic epithelium in human and mouse, with earlier gestation having a higher surface/cytoplasm distribution. TLR4 remained high in mouse postnatal day 1 but the surface/cytoplasm distribution was reduced. TLR4 decreased in amount and then was expressed in crypts in the mature human and mouse colon. Hydrocortisone (HC) reduced the surface/cytoplasm distribution of TLR4 in human fetal colon. Elevated IL-6 levels in immature colon after lipopolysaccharide were attenuated by HC in human and mouse. CONCLUSION: Expression, localization, and signaling of TLR4 in colonic epithelium may be developmentally regulated. HC may accelerate the TLR developmental pathway change to an adult type, which may account for its impact on TLR4 signaling. |Animals [MESH] |Colon/*cytology [MESH] |Enterocolitis, Necrotizing/*genetics [MESH] |Enzyme-Linked Immunosorbent Assay [MESH] |Epithelial Cells/metabolism/*physiology [MESH] |Gene Expression Regulation, Developmental/*physiology [MESH] |Humans [MESH] |Hydrocortisone/administration & dosage/*pharmacology [MESH] |Injections, Subcutaneous [MESH] |Interleukin-6/metabolism [MESH] |Mice [MESH] |Mice, Inbred C57BL [MESH] |Microscopy, Fluorescence [MESH]Toll-like receptor-4 in human and mouse colonic epithelium is developm(epmc).pdf DeepDyve Pubget Overpricing