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10.1038/ncomms8139 http://scihub22266oqcxt.onion/10.1038/ncomms8139 C4479041!4479041 !25972253     free     free     free Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25972253 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Nat+Commun 2015 ; 6 (ä): 7139 Nephropedia Template TP {{tp|p=25972253 |t=2015. Microbe-dependent lymphatic migration of neutrophils modulates lymphocyte proliferation in lymph nodes |pdf=|usr=}}{{25972253 }} gab.com Text Microbe-dependent lymphatic migration of neutrophils modulates lymphocyte proliferation in lymph nodes JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=25972253 #FOAvip Neutrophil recruitment to the site of injury is an essential first step of an anti-bacterial response. However, little is known about the basis for and relevance of neutrophil migration from inflamed tissue into lymphoid organs. We established a photoconversion-based system to monitor the fate of neutrophils recruited to inflamed skin. While neutrophils are efficiently recruited to sites of both microbial and sterile lesions, subsequent re-localization to draining lymph nodes happens only when bacteria are present in the primary lesion. Skin egress of neutrophils occurs via lymphatic vessels and is dependent on CD11b and CXCR4 but not CCR7. Neutrophils are the predominant immune cell to migrate from inflamed skin into lymph nodes where they augment lymphocyte proliferation. Furthermore, inhibition of neutrophil migration from skin reduces T-cell proliferation in draining lymph nodes. Thus neutrophils mediate rapid cellular communication between the initial injury site and secondary lymphoid organs and modulate immune responsiveness. Twit Text FOAVip Microbe-dependent lymphatic migration of neutrophils modulates lymphocyte proliferation in lymph nodes ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=25972253 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25972253 #FOAvip English Wikipedia <ref>{{Cite pmid|25972253 }}</ref> Microbe-dependent lymphatic migration of neutrophils modulates lymphocyte proliferation in lymph nodes #MMPMID25972253 Hampton HR ; Bailey J ; Tomura M ; Brink R ; Chtanova T Nat Commun 2015[May]; 6 (ä): 7139 PMID25972253 show ga Neutrophil recruitment to the site of injury is an essential first step of an anti-bacterial response. However, little is known about the basis for and relevance of neutrophil migration from inflamed tissue into lymphoid organs. We established a photoconversion-based system to monitor the fate of neutrophils recruited to inflamed skin. While neutrophils are efficiently recruited to sites of both microbial and sterile lesions, subsequent re-localization to draining lymph nodes happens only when bacteria are present in the primary lesion. Skin egress of neutrophils occurs via lymphatic vessels and is dependent on CD11b and CXCR4 but not CCR7. Neutrophils are the predominant immune cell to migrate from inflamed skin into lymph nodes where they augment lymphocyte proliferation. Furthermore, inhibition of neutrophil migration from skin reduces T-cell proliferation in draining lymph nodes. Thus neutrophils mediate rapid cellular communication between the initial injury site and secondary lymphoid organs and modulate immune responsiveness. |*Neutrophil Infiltration [MESH] |Animals [MESH] |Bacterial Infections/blood [MESH] |CD11b Antigen/biosynthesis [MESH] |Cell Movement [MESH] |Female [MESH] |Immune System [MESH] |Inflammation [MESH] |Lymph Nodes/*pathology [MESH] |Lymphatic Vessels [MESH] |Lymphocyte Activation/immunology [MESH] |Lymphocytes/cytology/*microbiology [MESH] |Male [MESH] |Mice [MESH] |Mice, Inbred C57BL [MESH] |Neutrophils/cytology/*microbiology [MESH] |Phenotype [MESH] |Receptors, CCR7/biosynthesis [MESH] |Receptors, CXCR4/biosynthesis [MESH] |Skin/microbiology [MESH]Microbe-dependent lymphatic migration of neutrophils modulates lymphoc(epmc).pdf DeepDyve Pubget Overpricing