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2015 ; 5
(ä): 27
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English Wikipedia
Apoptotic cell-linked immunoregulation: implications for promoting immune
tolerance in transplantation
#MMPMID26110047
Kuang R
; Perruche S
; Chen W
Cell Biosci
2015[]; 5
(ä): 27
PMID26110047
show ga
The induction of alloantigen-specific immune tolerance is the "Holy-Grail" in
transplantation. Although it had been previously demonstrated that transient
depletion of T cells through apoptosis could lead to long-term immune tolerance,
the underlying mechanism responsible for this tolerance induction and maintenance
was unknown. In this short article, a novel mechanism for long-term immune
tolerance via transient T cell apoptosis will be discussed, based on our recent
findings in a CD3-specific antibody treatment-induced immune tolerance mouse
model. Transforming growth factor-?, which is produced by immature dendritic
cells whilst they phagocytose apoptotic T cells and by macrophages, plays an
important role in initiating long-term immune tolerance. A possible model of how
allospecific-immune tolerance can be induced in order to prevent allograft
rejection in transplantation will be also proposed.