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10.1186/s13045-015-0156-y http://scihub22266oqcxt.onion/10.1186/s13045-015-0156-y C4478639!4478639!26022250     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Hematol+Oncol 2015 ; 8 (ä): ä Nephropedia Template TP {{tp|p=26022250|t=2015. Quantitative evaluation of the immunodeficiency of a mouse strain by tumor engraftments |pdf=|usr=}}{{26022250}} gab.com Text Quantitative evaluation of the immunodeficiency of a mouse strain by tumor engraftments JO: J Hematol Oncol http://www.kidney.de/pget.php?&tw=1&pmid=26022250 #FOAvip Background: The mouse is an organism that is widely used as a mammalian model for studying human physiology or disease, and the development of immunodeficient mice has provided a valuable tool for basic and applied human disease research. Following the development of large-scale mouse knockout programs and genome-editing tools, it has become increasingly efficient to generate genetically modified mouse strains with immunodeficiency. However, due to the lack of a standardized system for evaluating the immuno-capacity that prevents tumor progression in mice, an objective choice of the appropriate immunodeficient mouse strains to be used for tumor engrafting experiments is difficult. Methods: In this study, we developed a tumor engraftment index (TEI) to quantify the immunodeficiency response to hematologic malignant cells and solid tumor cells of six immunodeficient mouse strains and C57BL/6 wild-type mouse (WT). Results: Mice with a more severely impaired immune system attained a higher TEI score. We then validated that the NOD-scid-IL2Rg?/? (NSI) mice, which had the highest TEI score, were more suitable for xenograft and allograft experiments using multiple functional assays. Conclusions: The TEI score was effectively able to reflect the immunodeficiency of a mouse strain. Electronic supplementary material: The online version of this article (doi:10.1186/s13045-015-0156-y) contains supplementary material, which is available to authorized users. Twit Text FOAVip Quantitative evaluation of the immunodeficiency of a mouse strain by tumor engraftments ????J Hematol Oncol http://www.kidney.de/pget.php?&tw=1&pmid=26022250 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26022250 #FOAvip English Wikipedia <ref>{{Cite pmid|26022250}}</ref> Quantitative evaluation of the immunodeficiency of a mouse strain by tumor engraftments #MMPMID26022250 Ye W; Jiang Z; Li GX; Xiao Y; Lin S; Lai Y; Wang S; Li B; Jia B; Li Y; Huang Zl; Li J; Feng F; Li S; Yao H; Liu Z; Cao S; Xu L; Li Y; Wu D; Zeng L; Zhong M; Liu P; Wen Zs; Xu B; Yao Y; Pei D; Li P J Hematol Oncol 2015[]; 8 (ä): ä PMID26022250show ga Background: The mouse is an organism that is widely used as a mammalian model for studying human physiology or disease, and the development of immunodeficient mice has provided a valuable tool for basic and applied human disease research. Following the development of large-scale mouse knockout programs and genome-editing tools, it has become increasingly efficient to generate genetically modified mouse strains with immunodeficiency. However, due to the lack of a standardized system for evaluating the immuno-capacity that prevents tumor progression in mice, an objective choice of the appropriate immunodeficient mouse strains to be used for tumor engrafting experiments is difficult. Methods: In this study, we developed a tumor engraftment index (TEI) to quantify the immunodeficiency response to hematologic malignant cells and solid tumor cells of six immunodeficient mouse strains and C57BL/6 wild-type mouse (WT). Results: Mice with a more severely impaired immune system attained a higher TEI score. We then validated that the NOD-scid-IL2Rg?/? (NSI) mice, which had the highest TEI score, were more suitable for xenograft and allograft experiments using multiple functional assays. Conclusions: The TEI score was effectively able to reflect the immunodeficiency of a mouse strain. Electronic supplementary material: The online version of this article (doi:10.1186/s13045-015-0156-y) contains supplementary material, which is available to authorized users. äQuantitative evaluation of the immunodeficiency of a mouse strain by t(epmc).pdf DeepDyve Pubget Overpricing