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10.1002/psc.2731 http://scihub22266oqcxt.onion/10.1002/psc.2731 C4478595!4478595!25522925     free     free     free       J+Pept+Sci 2015 ; 21 (3): 236-42 Nephropedia Template TP {{tp|p=25522925|t=2015. Small-molecule inhibitors of JC polyomavirus infection |pdf=|usr=}}{{25522925}} gab.com Text Small-molecule inhibitors of JC polyomavirus infection JO: J Pept Sci http://www.kidney.de/pget.php?&tw=1&pmid=25522925 #FOAvip The JC polyomavirus (JCPyV) infects approximately 50% of the human population. In healthy individuals the infection remains dormant and asymptomatic, but in immuno-suppressed patients it can cause progressive multifocal leukoencephalopathy (PML), a potentially fatal demyelinating disease. Currently, there are no drugs against JCPyV infection, nor for the treatment of PML. Here, we report the development of small molecule inhibitors of JCPyV that target the initial interaction between the virus and host cell and thereby block viral entry. Utilizing a combination of computational and NMR-based screening techniques, we target the LSTc tetrasaccharide binding site within the VP1 pentameric coat protein of JCPyV. Four of the compounds from the screen effectively block viral infection in our in vitro assays using SVG-A cells. For the most potent compound, we used saturation transfer difference NMR to determine the mode of binding to purified pentamers of JCPyV VP1. Collectively these results demonstrate the viability of this class of compounds for eventual development of JCPyV-antiviral therapeutics. Twit Text FOAVip Small-molecule inhibitors of JC polyomavirus infection ????J Pept Sci http://www.kidney.de/pget.php?&tw=1&pmid=25522925 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25522925 #FOAvip English Wikipedia <ref>{{Cite pmid|25522925}}</ref> Small-molecule inhibitors of JC polyomavirus infection #MMPMID25522925 Yatawara A; Gaidos G; Rupasinghe CN; O?Hara BA; Pellegrini M; Atwood WJ; Mierke DF J Pept Sci 2015[Mar]; 21 (3): 236-42 PMID25522925show ga The JC polyomavirus (JCPyV) infects approximately 50% of the human population. In healthy individuals the infection remains dormant and asymptomatic, but in immuno-suppressed patients it can cause progressive multifocal leukoencephalopathy (PML), a potentially fatal demyelinating disease. Currently, there are no drugs against JCPyV infection, nor for the treatment of PML. Here, we report the development of small molecule inhibitors of JCPyV that target the initial interaction between the virus and host cell and thereby block viral entry. Utilizing a combination of computational and NMR-based screening techniques, we target the LSTc tetrasaccharide binding site within the VP1 pentameric coat protein of JCPyV. Four of the compounds from the screen effectively block viral infection in our in vitro assays using SVG-A cells. For the most potent compound, we used saturation transfer difference NMR to determine the mode of binding to purified pentamers of JCPyV VP1. Collectively these results demonstrate the viability of this class of compounds for eventual development of JCPyV-antiviral therapeutics. äSmall-molecule inhibitors of JC polyomavirus infection (epmc).pdf DeepDyve Pubget Overpricing