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10.4239/wjd.v6.i6.840

http://scihub22266oqcxt.onion/10.4239/wjd.v6.i6.840
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C4478579!4478579!26131325
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suck abstract from ncbi


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pmid26131325      World+J+Diabetes 2015 ; 6 (6): 840-9
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  • Diabetes therapies in hemodialysis patients: Dipeptidase-4 inhibitors #MMPMID26131325
  • Nakamura Y; Hasegawa H; Tsuji M; Udaka Y; Mihara M; Shimizu T; Inoue M; Goto Y; Gotoh H; Inagaki M; Oguchi K
  • World J Diabetes 2015[Jun]; 6 (6): 840-9 PMID26131325show ga
  • Although several previous studies have been published on the effects of dipeptidase-4 (DPP-4) inhibitors in diabetic hemodialysis (HD) patients, the findings have yet to be reviewed comprehensively. Eyesight failure caused by diabetic retinopathy and aging-related dementia make multiple daily insulin injections difficult for HD patients. Therefore, we reviewed the effects of DPP-4 inhibitors with a focus on oral antidiabetic drugs as a new treatment strategy in HD patients with diabetes. The following 7 DPP-4 inhibitors are available worldwide: sitagliptin, vildagliptin, alogliptin, linagliptin, teneligliptin, anagliptin, and saxagliptin. All of these are administered once daily with dose adjustments in HD patients. Four types of oral antidiabetic drugs can be administered for combination oral therapy with DPP-4 inhibitors, including sulfonylureas, meglitinide, thiazolidinediones, and alpha-glucosidase inhibitor. Nine studies examined the antidiabetic effects in HD patients. Treatments decreased hemoglobin A1c and glycated albumin levels by 0.3% to 1.3% and 1.7% to 4.9%, respectively. The efficacy of DPP-4 inhibitor treatment is high among HD patients, and no patients exhibited significant severe adverse effects such as hypoglycemia and liver dysfunction. DPP-4 inhibitors are key drugs in new treatment strategies for HD patients with diabetes and with limited choices for diabetes treatment.
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