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C4477872!4477872!25679649
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pmid25679649      Phys+Rev+E+Stat+Nonlin+Soft+Matter+Phys 2015 ; 91 (1): 012714
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  • Quasispecies Theory for Evolution of Modularity #MMPMID25679649
  • Park JM; Niestemski LR; Deem MW
  • Phys Rev E Stat Nonlin Soft Matter Phys 2015[Jan]; 91 (1): 012714 PMID25679649show ga
  • Biological systems are modular, and this modularity evolves over time and in different environments. A number of observations have been made of increased modularity in biological systems under increased environmental pressure. We here develop a quasispecies theory for the dynamics of modularity in populations of these systems. We show how the steady-state fitness in a randomly changing environment can be computed. We derive a fluctuation dissipation relation for the rate of change of modularity and use it to derive a relationship between rate of environmental changes and rate of growth of modularity. We also find a principle of least action for the evolved modularity at steady state. Finally, we compare our predictions to simulations of protein evolution and find them to be consistent.
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