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Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Semin+Cardiothorac+Vasc+Anesth 2015 ; 19 (1): 49-60 Nephropedia Template TP
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Circadian Rhythms in Anesthesia and Critical Care Medicine: Potential importance of circadian disruptions #MMPMID25294583
Brainard J; Gobel M; Bartels K; Scott B; Koeppen M; Eckle T
Semin Cardiothorac Vasc Anesth 2015[Mar]; 19 (1): 49-60 PMID25294583show ga
The rotation of the earth and associated alternating cycles of light and dark?the basis of our circadian rhythms?are fundamental to human biology and culture. However, it was not until 1971 that researchers first began to describe the molecular mechanisms for the circadian system. During the last few years, groundbreaking research has revealed a multitude of circadian genes affecting a variety of clinical diseases, including diabetes, obesity, sepsis, cardiac ischemia, and sudden cardiac death. Anesthesiologists, in the operating room and intensive care units, manage these diseases on a daily basis as they significantly impact patient outcomes. Intriguingly, sedatives, anesthetics, and the ICU environment have all been shown to disrupt the circadian system in patients. In the current review we will discuss how newly acquired knowledge of circadian rhythms could lead to changes in clinical practice and new therapeutic concepts.