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Circadian rhythms in anesthesia and critical care medicine: potential importance
of circadian disruptions
#MMPMID25294583
Brainard J
; Gobel M
; Bartels K
; Scott B
; Koeppen M
; Eckle T
Semin Cardiothorac Vasc Anesth
2015[Mar]; 19
(1
): 49-60
PMID25294583
show ga
The rotation of the earth and associated alternating cycles of light and
dark--the basis of our circadian rhythms--are fundamental to human biology and
culture. However, it was not until 1971 that researchers first began to describe
the molecular mechanisms for the circadian system. During the past few years,
groundbreaking research has revealed a multitude of circadian genes affecting a
variety of clinical diseases, including diabetes, obesity, sepsis, cardiac
ischemia, and sudden cardiac death. Anesthesiologists, in the operating room and
intensive care units, manage these diseases on a daily basis as they
significantly affect patient outcomes. Intriguingly, sedatives, anesthetics, and
the intensive care unit environment have all been shown to disrupt the circadian
system in patients. In the current review, we will discuss how newly acquired
knowledge of circadian rhythms could lead to changes in clinical practice and new
therapeutic concepts.
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