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10.1186/s13000-015-0260-x http://scihub22266oqcxt.onion/10.1186/s13000-015-0260-x C4477497!4477497!26065676     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Diagn+Pathol 2015 ; 10 (ä): ä Nephropedia Template TP {{tp|p=26065676|t=2015. A critical role of mir-199a in the cell biological behaviors of colorectal cancer |pdf=|usr=}}{{26065676}} gab.com Text A critical role of mir-199a in the cell biological behaviors of colorectal cancer JO: Diagn Pathol http://www.kidney.de/pget.php?&tw=1&pmid=26065676 #FOAvip Background: Colorectal cancer (CRC) is one of the most common cancer and the leading causes of cancer mortality worldwide. The critical role of hypoxia-inducible factor 1? (HIF-1?) and vascular endothelial growth factor (VEGF) are important in the cancer development. Methods: The purpose of this study was to investigate the association of miR-199a expression in CRC and non-tumor tissues as well as assessed the effect of miR-199a on biological behaviors including cell proliferation, apoptosis, migration and invasion of CRC cells. The expression of miR-199a was distinctly decreased in colorectal cancer tissues compared with non-neoplastic colorectal tissues. Results: In this study, we found that miR-199a down-regulation was associated with the CRC and metastasis incidence. Advanced study showed that miR-199a up-regulation would lead to decreased CRC proliferation, migration and invasion. However, no significant association of miR-199a treatment and apoptosis rate and cell-cycle were detected in this study. The detection for the mechanisms of miR-199a on the development of CRC showed that the anticarcinogenic effect of miR-199a might be produced through HIF-1?/VEGF pathway. Conclusion: It was found that miR-199a would reduce the proliferation, migration and invasion. However, overexpression of miR-199a on the apoptosis rate and cell cycles showed no significant results. The potential functionary mechanism of miR-199a might through HIF-1?/VEGF pathway. Virtual slides: The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/9806714131513041. Twit Text FOAVip A critical role of mir-199a in the cell biological behaviors of colorectal cancer ????Diagn Pathol http://www.kidney.de/pget.php?&tw=1&pmid=26065676 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26065676 #FOAvip English Wikipedia <ref>{{Cite pmid|26065676}}</ref> A critical role of mir-199a in the cell biological behaviors of colorectal cancer #MMPMID26065676 Ye H; Pang L; Wu Q; Zhu Y; Guo C; Deng Y; Zheng X Diagn Pathol 2015[]; 10 (ä): ä PMID26065676show ga Background: Colorectal cancer (CRC) is one of the most common cancer and the leading causes of cancer mortality worldwide. The critical role of hypoxia-inducible factor 1? (HIF-1?) and vascular endothelial growth factor (VEGF) are important in the cancer development. Methods: The purpose of this study was to investigate the association of miR-199a expression in CRC and non-tumor tissues as well as assessed the effect of miR-199a on biological behaviors including cell proliferation, apoptosis, migration and invasion of CRC cells. The expression of miR-199a was distinctly decreased in colorectal cancer tissues compared with non-neoplastic colorectal tissues. Results: In this study, we found that miR-199a down-regulation was associated with the CRC and metastasis incidence. Advanced study showed that miR-199a up-regulation would lead to decreased CRC proliferation, migration and invasion. However, no significant association of miR-199a treatment and apoptosis rate and cell-cycle were detected in this study. The detection for the mechanisms of miR-199a on the development of CRC showed that the anticarcinogenic effect of miR-199a might be produced through HIF-1?/VEGF pathway. Conclusion: It was found that miR-199a would reduce the proliferation, migration and invasion. However, overexpression of miR-199a on the apoptosis rate and cell cycles showed no significant results. The potential functionary mechanism of miR-199a might through HIF-1?/VEGF pathway. Virtual slides: The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/9806714131513041. äA critical role of mir-199a in the cell biological behaviors of colore(epmc).pdf DeepDyve Pubget Overpricing