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Molecular Imaging of Membrane Transporters? Activity in Cancer: a Picture is Worth a Thousand Tubes #MMPMID25823669
Mann A; Semenenko I; Meir M; Eyal S
AAPS J 2015[Jul]; 17 (4): 788-801 PMID25823669show ga
Molecular imaging allows the non-invasive assessment of membrane transporter expression and function in living subjects. Such technologies have the potential to become diagnostic and prognostic tools, allowing detection, localization, and prediction of response of tumors and their metastases to therapy. Beyond tumors, imaging can also help understand the role of transporters in adverse drug effects and drug clearance. Here, we review molecular imaging technologies that monitor transporter-mediated processes. We emphasize emerging probe substrates and potential clinical applications of imaging the function of membrane transporters in cancer.