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10.1038/onc.2014.410 http://scihub22266oqcxt.onion/10.1038/onc.2014.410 C4476970!4476970 !25531323     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25531323 &cmd=llinks): Failed to open stream: HTTP request failed! 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Osteopontin mediates an MZF1-TGF-?1-dependent transformation of mesenchymal stem cells into cancer-associated fibroblasts in breast cancer |pdf=|usr=}}{{25531323 }} gab.com Text Osteopontin mediates an MZF1-TGF- 1-dependent transformation of mesenchymal stem cells into cancer-associated fibroblasts in breast cancer JO: Oncogene http://www.kidney.de/pget.php?&tw=1&pmid=25531323 #FOAvip Interactions between tumor cells and cancer-associated fibroblasts (CAFs) in the tumor microenvironment significantly influence cancer growth and metastasis. Transforming growth factor-? (TGF-?) is known to be a critical mediator of the CAF phenotype, and osteopontin (OPN) expression in tumors is associated with more aggressive phenotypes and poor patient outcomes. The potential link between these two pathways has not been previously addressed. Utilizing in vitro studies using human mesenchymal stem cells (MSCs) and MDA-MB231 (OPN+) and MCF7 (OPN-) human breast cancer cell lines, we demonstrate that OPN induces integrin-dependent MSC expression of TGF-?1 to mediate adoption of the CAF phenotype. This OPN-TGF-?1 pathway requires the transcription factor, myeloid zinc finger 1 (MZF1). In vivo studies with xenotransplant models in NOD-scid mice showed that OPN expression increases cancer growth and metastasis by mediating MSC-to-CAF transformation in a process that is MZF1 and TGF-?1 dependent. We conclude that tumor-derived OPN engenders MSC-to-CAF transformation in the microenvironment to promote tumor growth and metastasis via the OPN-MZF1-TGF-?1 pathway. Twit Text FOAVip Osteopontin mediates an MZF1-TGF- 1-dependent transformation of mesenchymal stem cells into cancer-associated fibroblasts in breast cancer ????Oncogene http://www.kidney.de/pget.php?&tw=1&pmid=25531323 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25531323 #FOAvip English Wikipedia <ref>{{Cite pmid|25531323 }}</ref> Osteopontin mediates an MZF1-TGF-?1-dependent transformation of mesenchymal stem cells into cancer-associated fibroblasts in breast cancer #MMPMID25531323 Weber CE ; Kothari AN ; Wai PY ; Li NY ; Driver J ; Zapf MA ; Franzen CA ; Gupta GN ; Osipo C ; Zlobin A ; Syn WK ; Zhang J ; Kuo PC ; Mi Z Oncogene 2015[Sep]; 34 (37 ): 4821-33 PMID25531323 show ga Interactions between tumor cells and cancer-associated fibroblasts (CAFs) in the tumor microenvironment significantly influence cancer growth and metastasis. Transforming growth factor-? (TGF-?) is known to be a critical mediator of the CAF phenotype, and osteopontin (OPN) expression in tumors is associated with more aggressive phenotypes and poor patient outcomes. The potential link between these two pathways has not been previously addressed. Utilizing in vitro studies using human mesenchymal stem cells (MSCs) and MDA-MB231 (OPN+) and MCF7 (OPN-) human breast cancer cell lines, we demonstrate that OPN induces integrin-dependent MSC expression of TGF-?1 to mediate adoption of the CAF phenotype. This OPN-TGF-?1 pathway requires the transcription factor, myeloid zinc finger 1 (MZF1). In vivo studies with xenotransplant models in NOD-scid mice showed that OPN expression increases cancer growth and metastasis by mediating MSC-to-CAF transformation in a process that is MZF1 and TGF-?1 dependent. We conclude that tumor-derived OPN engenders MSC-to-CAF transformation in the microenvironment to promote tumor growth and metastasis via the OPN-MZF1-TGF-?1 pathway. |Animals [MESH] |Breast Neoplasms/genetics/metabolism/*pathology [MESH] |Cell Transformation, Neoplastic/genetics/*metabolism [MESH] |Female [MESH] |Fibroblasts/drug effects/metabolism/*pathology [MESH] |Humans [MESH] |Kruppel-Like Transcription Factors/genetics/metabolism [MESH] |MCF-7 Cells [MESH] |Mesenchymal Stem Cells/metabolism/*pathology [MESH] |Mice [MESH] |Mice, Inbred NOD [MESH] |Mice, SCID [MESH] |Neoplastic Stem Cells/drug effects/metabolism/*pathology [MESH] |Osteopontin/pharmacology/*physiology [MESH] |Signal Transduction/drug effects/genetics [MESH] |Transforming Growth Factor beta1/genetics/metabolism [MESH]Osteopontin mediates an MZF1-TGF-?1-dependent transformation of mesenc(epmc).pdf DeepDyve Pubget Overpricing