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10.1097/WCO.0000000000000183 http://scihub22266oqcxt.onion/10.1097/WCO.0000000000000183 C4476903!4476903!25734952     free     free     free Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Curr+Opin+Neurol 2015 ; 28 (2): 103-9 Nephropedia Template TP {{tp|p=25734952|t=2015. The utility of rodent models of autism spectrum disorders |pdf=|usr=}}{{25734952}} gab.com Text The utility of rodent models of autism spectrum disorders JO: Curr Opin Neurol http://www.kidney.de/pget.php?&tw=1&pmid=25734952 #FOAvip Purpose of Review: This review discusses the ways rodent models of autism spectrum disorders (ASDs) have been used to gain critical information convergent molecular pathways, the mechanisms underlying altered microcircuit structure and function, and as a screen for potential cutting edge-treatments. Recent Findings: There is convergent evidence that impaired developmental pruning of connections may be a common finding among several mouse models of ASDs. Recent studies have uncovered impaired autophagy by pathological mTOR activation as a potential contributor to microcircuit dysfunction and behavior. ASD related disinhibition and exaggerated synaptic plasticity in multiple distinct circuits in cortex and reward circuits in striatum also contribute to social dysfunction and repetitive behaviors. New exciting molecular therapeutic techniques have reversed cognitive deficits in models of ASD, indicating that mouse models could be used for preclinical translational studies of new treatments. Summary: Rodent models of ASDs coupled to new emerging technologies for genome editing, cell-specific functional and structural imaging, and neuronal activity manipulation will yield critical insights into ASD pathogenesis and fuel the emergence of new treatments. Twit Text FOAVip The utility of rodent models of autism spectrum disorders ????Curr Opin Neurol http://www.kidney.de/pget.php?&tw=1&pmid=25734952 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25734952 #FOAvip English Wikipedia <ref>{{Cite pmid|25734952}}</ref> The utility of rodent models of autism spectrum disorders #MMPMID25734952 Lazaro M; Golshani P Curr Opin Neurol 2015[Apr]; 28 (2): 103-9 PMID25734952show ga Purpose of Review: This review discusses the ways rodent models of autism spectrum disorders (ASDs) have been used to gain critical information convergent molecular pathways, the mechanisms underlying altered microcircuit structure and function, and as a screen for potential cutting edge-treatments. Recent Findings: There is convergent evidence that impaired developmental pruning of connections may be a common finding among several mouse models of ASDs. Recent studies have uncovered impaired autophagy by pathological mTOR activation as a potential contributor to microcircuit dysfunction and behavior. ASD related disinhibition and exaggerated synaptic plasticity in multiple distinct circuits in cortex and reward circuits in striatum also contribute to social dysfunction and repetitive behaviors. New exciting molecular therapeutic techniques have reversed cognitive deficits in models of ASD, indicating that mouse models could be used for preclinical translational studies of new treatments. Summary: Rodent models of ASDs coupled to new emerging technologies for genome editing, cell-specific functional and structural imaging, and neuronal activity manipulation will yield critical insights into ASD pathogenesis and fuel the emergence of new treatments. äThe utility of rodent models of autism spectrum disorders (epmc).pdf DeepDyve Pubget Overpricing