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10.1080/07474946.2012.719433 http://scihub22266oqcxt.onion/10.1080/07474946.2012.719433 C4476492!4476492!26109746     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Seq+Anal 2012 ; 31 (4): 441-57 Nephropedia Template TP {{tp|p=26109746|t=2012. Efficient Adaptive Randomization and Stopping Rules in Multi-arm Clinical Trials for Testing a New Treatment |pdf=|usr=}}{{26109746}} gab.com Text Efficient Adaptive Randomization and Stopping Rules in Multi-arm Clinical Trials for Testing a New Treatment JO: Seq Anal http://www.kidney.de/pget.php?&tw=1&pmid=26109746 #FOAvip Motivated by applications to confirmatory clinical trials for testing a new treatment against a placebo or active control when the new treatment has k possible treatment strategies (arms)?for example, k possible doses for a new drug?we develop an asymptotic theory for efficient outcome-adaptive randomization schemes and optimal stopping rules. Our approach consists of developing asymptotic lower bounds for the expected sample sizes from the k treatment arms and the control arm and using generalized sequential likelihood ratio procedures to achieve these bounds. Implementation details of our design and analysis and comparative simulation studies are also provided. Twit Text FOAVip Efficient Adaptive Randomization and Stopping Rules in Multi-arm Clinical Trials for Testing a New Treatment ????Seq Anal http://www.kidney.de/pget.php?&tw=1&pmid=26109746 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26109746 #FOAvip English Wikipedia <ref>{{Cite pmid|26109746}}</ref> Efficient Adaptive Randomization and Stopping Rules in Multi-arm Clinical Trials for Testing a New Treatment #MMPMID26109746 Lai TL; Liao OYW Seq Anal 2012[]; 31 (4): 441-57 PMID26109746show ga Motivated by applications to confirmatory clinical trials for testing a new treatment against a placebo or active control when the new treatment has k possible treatment strategies (arms)?for example, k possible doses for a new drug?we develop an asymptotic theory for efficient outcome-adaptive randomization schemes and optimal stopping rules. Our approach consists of developing asymptotic lower bounds for the expected sample sizes from the k treatment arms and the control arm and using generalized sequential likelihood ratio procedures to achieve these bounds. Implementation details of our design and analysis and comparative simulation studies are also provided. äEfficient Adaptive Randomization and Stopping Rules in Multi-arm Clini(epmc).pdf DeepDyve Pubget Overpricing