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Effects of indacaterol versus tiotropium on respiratory mechanics assessed by the
forced oscillation technique in patients with chronic obstructive pulmonary
disease
#MMPMID26124653
Inui N
; Matsushima S
; Kato S
; Yasui H
; Kono M
; Fujisawa T
; Enomoto N
; Nakamura Y
; Toyoshima M
; Suda T
Int J Chron Obstruct Pulmon Dis
2015[]; 10
(?): 1139-46
PMID26124653
show ga
The forced oscillation technique (FOT) can measure respiratory mechanics and has
attracted attention in chronic obstructive pulmonary disease (COPD). We aimed to
evaluate the effects of only indacaterol and tiotropium monotherapies on airflow
limitation and respiratory impedance. Pulmonary function tests, COPD assessment
test (CAT), and multifrequency FOT with MostGraph-01 were performed at the
beginning and after 8 weeks of treatment with indacaterol or tiotropium. The
resistance index, resistance at 5 Hz (R5), resistance at 20 Hz (R20), reactance
index, reactance at 5 Hz (X5), resonant frequency (Fres), and low-frequency
reactance area (ALX) were determined at whole-breath, inspiratory, and expiratory
phases. Eighty-two patients (mean age: 73 years; mean forced expiratory volume in
1 second (FEV1): 61.6%±19.0% predicted) were randomized to indacaterol or
tiotropium treatment. Both bronchodilators improved airflow limitation, with mean
trough improvements in FEV1 of 165 mL and 80 mL in the indacaterol and tiotropium
groups, respectively. The CAT score decreased in the indacaterol group (P<0.001;
11.2±6.6 to 7.5±5.6). Compared with tiotropium, indacaterol significantly
improved FEV1, percent predicted FEV1, and CAT score (P=0.042, P=0.008, and
P=0.027, respectively). For respiratory impedance, indacaterol and tiotropium
changed R5, X5, Fres, and ALX at whole-breath, inspiratory, and expiratory
phases. In the indacaterol group, the changes in R5, R5-R20, X5, Fres, and ALX
were significantly correlated with the changes in FEV1. The use of the FOT may
enable the evaluation of the effects of bronchodilators in addition to
FEV1-indicated therapeutic effects in COPD.
|Adrenergic beta-2 Receptor Agonists/adverse effects/*therapeutic use
[MESH]
|Aged
[MESH]
|Aged, 80 and over
[MESH]
|Airway Resistance/drug effects
[MESH]
|Bronchodilator Agents/adverse effects/*therapeutic use
[MESH]
|Female
[MESH]
|Forced Expiratory Volume
[MESH]
|Humans
[MESH]
|Indans/adverse effects/*therapeutic use
[MESH]
|Japan
[MESH]
|Lung/*drug effects/physiopathology
[MESH]
|Male
[MESH]
|Middle Aged
[MESH]
|Muscarinic Antagonists/adverse effects/*therapeutic use
[MESH]
free
free
free
