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10.1016/j.fob.2015.05.007

http://scihub22266oqcxt.onion/10.1016/j.fob.2015.05.007
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C4475775!4475775!26106522
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suck abstract from ncbi


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pmid26106522      FEBS+Open+Bio 2015 ; 5 (ä): 476-84
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  • Hyaluronic acid regulates a key redox control factor Nrf2 via phosphorylation of Akt in bovine articular chondrocytes #MMPMID26106522
  • Onodera Y; Teramura T; Takehara T; Fukuda K
  • FEBS Open Bio 2015[]; 5 (ä): 476-84 PMID26106522show ga
  • ?Hyaluronic acid (HA) has a pharmacological role for reduction of cellular superoxide.?In HA-treated chondrocytes, expression of Nrf2 and its downstream genes was upregulated.?Inhibition of Akt or suppression of HA receptors prevented HA-mediated Nrf2 accumulation.?Nrf2 siRNA inhibited the HA effect on antioxidant enzymes.?HA might contribute to ROS reduction through Nrf2 regulation by activating Akt.
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