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10.1007/s10456-012-9271-3 http://scihub22266oqcxt.onion/10.1007/s10456-012-9271-3 C4475587!4475587 !22535383     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=22535383 &cmd=llinks): Failed to open stream: HTTP request failed! 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Quantitative assessment of tumor angiogenesis using real-time motion-compensated contrast-enhanced ultrasound imaging |pdf=|usr=}}{{22535383 }} gab.com Text Quantitative assessment of tumor angiogenesis using real-time motion-compensated contrast-enhanced ultrasound imaging JO: Angiogenesis http://www.kidney.de/pget.php?&tw=1&pmid=22535383 #FOAvip PURPOSE: To develop and test a real-time motion compensation algorithm for contrast-enhanced ultrasound imaging of tumor angiogenesis on a clinical ultrasound system. MATERIALS AND METHODS: The Administrative Institutional Panel on Laboratory Animal Care approved all experiments. A new motion correction algorithm measuring the sum of absolute differences in pixel displacements within a designated tracking box was implemented in a clinical ultrasound machine. In vivo angiogenesis measurements (expressed as percent contrast area) with and without motion compensated maximum intensity persistence (MIP) ultrasound imaging were analyzed in human colon cancer xenografts (n = 64) in mice. Differences in MIP ultrasound imaging signal with and without motion compensation were compared and correlated with displacements in x- and y-directions. The algorithm was tested in an additional twelve colon cancer xenograft-bearing mice with (n = 6) and without (n = 6) anti-vascular therapy (ASA-404). In vivo MIP percent contrast area measurements were quantitatively correlated with ex vivo microvessel density (MVD) analysis. RESULTS: MIP percent contrast area was significantly different (P < 0.001) with and without motion compensation. Differences in percent contrast area correlated significantly (P < 0.001) with x- and y-displacements. MIP percent contrast area measurements were more reproducible with motion compensation (ICC = 0.69) than without (ICC = 0.51) on two consecutive ultrasound scans. Following anti-vascular therapy, motion-compensated MIP percent contrast area significantly (P = 0.03) decreased by 39.4 ± 14.6 % compared to non-treated mice and correlated well with ex vivo MVD analysis (Rho = 0.70; P = 0.05). CONCLUSION: Real-time motion-compensated MIP ultrasound imaging allows reliable and accurate quantification and monitoring of angiogenesis in tumors exposed to breathing-induced motion artifacts. Twit Text FOAVip Quantitative assessment of tumor angiogenesis using real-time motion-compensated contrast-enhanced ultrasound imaging ????Angiogenesis http://www.kidney.de/pget.php?&tw=1&pmid=22535383 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=22535383 #FOAvip English Wikipedia <ref>{{Cite pmid|22535383 }}</ref> Quantitative assessment of tumor angiogenesis using real-time motion-compensated contrast-enhanced ultrasound imaging #MMPMID22535383 Pysz MA ; Guracar I ; Foygel K ; Tian L ; Willmann JK Angiogenesis 2012[Sep]; 15 (3 ): 433-42 PMID22535383 show ga PURPOSE: To develop and test a real-time motion compensation algorithm for contrast-enhanced ultrasound imaging of tumor angiogenesis on a clinical ultrasound system. MATERIALS AND METHODS: The Administrative Institutional Panel on Laboratory Animal Care approved all experiments. A new motion correction algorithm measuring the sum of absolute differences in pixel displacements within a designated tracking box was implemented in a clinical ultrasound machine. In vivo angiogenesis measurements (expressed as percent contrast area) with and without motion compensated maximum intensity persistence (MIP) ultrasound imaging were analyzed in human colon cancer xenografts (n = 64) in mice. Differences in MIP ultrasound imaging signal with and without motion compensation were compared and correlated with displacements in x- and y-directions. The algorithm was tested in an additional twelve colon cancer xenograft-bearing mice with (n = 6) and without (n = 6) anti-vascular therapy (ASA-404). In vivo MIP percent contrast area measurements were quantitatively correlated with ex vivo microvessel density (MVD) analysis. RESULTS: MIP percent contrast area was significantly different (P < 0.001) with and without motion compensation. Differences in percent contrast area correlated significantly (P < 0.001) with x- and y-displacements. MIP percent contrast area measurements were more reproducible with motion compensation (ICC = 0.69) than without (ICC = 0.51) on two consecutive ultrasound scans. Following anti-vascular therapy, motion-compensated MIP percent contrast area significantly (P = 0.03) decreased by 39.4 ± 14.6 % compared to non-treated mice and correlated well with ex vivo MVD analysis (Rho = 0.70; P = 0.05). CONCLUSION: Real-time motion-compensated MIP ultrasound imaging allows reliable and accurate quantification and monitoring of angiogenesis in tumors exposed to breathing-induced motion artifacts. |*Ultrasonics [MESH] |Algorithms [MESH] |Animals [MESH] |Female [MESH] |Fluorescent Antibody Technique [MESH] |Humans [MESH] |Mice [MESH] |Mice, Nude [MESH] |Neoplasms/*blood supply/diagnostic imaging/pathology [MESH] |Neovascularization, Pathologic/*diagnostic imaging [MESH] |Transplantation, Heterologous [MESH]Quantitative assessment of tumor angiogenesis using real-time motion-c(epmc).pdf DeepDyve Pubget Overpricing