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10.1016/j.molcel.2015.04.006 http://scihub22266oqcxt.onion/10.1016/j.molcel.2015.04.006 C4475495!4475495!26028540     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Mol+Cell 2015 ; 58 (6): 1101-12 Nephropedia Template TP {{tp|p=26028540|t=2015. Upstream Anti-sense Promoters are Hubs of Transcription Factor Binding and Active Histone Modifications |pdf=|usr=}}{{26028540}} gab.com Text Upstream Anti-sense Promoters are Hubs of Transcription Factor Binding and Active Histone Modifications JO: Mol Cell http://www.kidney.de/pget.php?&tw=1&pmid=26028540 #FOAvip Anti-sense transcription originating upstream of mammalian protein-coding genes is a well-documented phenomenon, but remarkably little is known about the regulation or function of anti-sense promoters and the non-coding RNAs they generate. Here we define at nucleotide resolution the divergent transcription start sites (TSSs) near mouse mRNA genes. We find that coupled sense and anti-sense TSSs precisely define the boundaries of a nucleosome-depleted region (NDR) that is highly enriched in transcription factor (TF) motifs. Notably, as the distance between sense and anti-sense TSSs increases, so does the size of the NDR, the level of signal-dependent TF binding and gene activation. We further discover a group of anti-sense TSSs in macrophages with an enhancer-like chromatin signature. Interestingly, this signature identifies divergent promoters that are activated during immune challenge. We propose that anti-sense promoters serve as platforms for TF binding and establishment of active chromatin to further regulate or enhance sense-strand mRNA expression. Twit Text FOAVip Upstream Anti-sense Promoters are Hubs of Transcription Factor Binding and Active Histone Modifications ????Mol Cell http://www.kidney.de/pget.php?&tw=1&pmid=26028540 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26028540 #FOAvip English Wikipedia <ref>{{Cite pmid|26028540}}</ref> Upstream Anti-sense Promoters are Hubs of Transcription Factor Binding and Active Histone Modifications #MMPMID26028540 Scruggs BS; Gilchrist DA; Nechaev S; Muse GW; Burkholder A; Fargo DC; Adelman K Mol Cell 2015[Jun]; 58 (6): 1101-12 PMID26028540show ga Anti-sense transcription originating upstream of mammalian protein-coding genes is a well-documented phenomenon, but remarkably little is known about the regulation or function of anti-sense promoters and the non-coding RNAs they generate. Here we define at nucleotide resolution the divergent transcription start sites (TSSs) near mouse mRNA genes. We find that coupled sense and anti-sense TSSs precisely define the boundaries of a nucleosome-depleted region (NDR) that is highly enriched in transcription factor (TF) motifs. Notably, as the distance between sense and anti-sense TSSs increases, so does the size of the NDR, the level of signal-dependent TF binding and gene activation. We further discover a group of anti-sense TSSs in macrophages with an enhancer-like chromatin signature. Interestingly, this signature identifies divergent promoters that are activated during immune challenge. We propose that anti-sense promoters serve as platforms for TF binding and establishment of active chromatin to further regulate or enhance sense-strand mRNA expression. äUpstream Anti-sense Promoters are Hubs of Transcription Factor Binding(epmc).pdf DeepDyve Pubget Overpricing