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10.1038/psp.2014.41 http://scihub22266oqcxt.onion/10.1038/psp.2014.41 C4474165!4474165!25353186     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       CPT+Pharmacometrics+Syst+Pharmacol 2014 ; 3 (10): e143- Nephropedia Template TP {{tp|p=25353186|t=2014. Simultaneous Exposure?Response Modeling of ACR20, ACR50, and ACR70 Improvement Scores in Rheumatoid Arthritis Patients Treated With Certolizumab Pegol |pdf=|usr=}}{{25353186}} gab.com Text Simultaneous Exposure Response Modeling of ACR20, ACR50, and ACR70 Improvement Scores in Rheumatoid Arthritis Patients Treated With Certolizumab Pegol JO: CPT Pharmacometrics Syst Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=25353186 #FOAvip The Markovian approach has been proposed to model American College of Rheumatology's (ACR) response (ACR20, ACR50, or ACR70) reported in rheumatoid arthritis clinical trials to account for the dependency of the scores over time. However, dichotomizing the composite ACR assessment discards much information. Here, we propose a new approach for modeling together the three thresholds: a continuous-time Markov exposure?response model was developed, based on data from five placebo-controlled certolizumab pegol clinical trials. This approach allows adequate prediction of individual ACR20/50/70 time-response, even for non-periodic observations. An exposure?response was established over a large range of licensed and unlicensed doses including phase II dose-ranging data. Simulations from the model (50?400?mg every other week) illustrated the range and sustainability of response (ACR20: 56?68%, ACR50: 27?42%, ACR70: 11?22% at week 24) with maximum clinical effect achieved at the recommended maintenance dose of 200?mg every other week. Twit Text FOAVip Simultaneous Exposure Response Modeling of ACR20, ACR50, and ACR70 Improvement Scores in Rheumatoid Arthritis Patients Treated With Certolizumab Pegol ????CPT Pharmacometrics Syst Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=25353186 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25353186 #FOAvip English Wikipedia <ref>{{Cite pmid|25353186}}</ref> Simultaneous Exposure?Response Modeling of ACR20, ACR50, and ACR70 Improvement Scores in Rheumatoid Arthritis Patients Treated With Certolizumab Pegol #MMPMID25353186 Lacroix BD; Karlsson MO; Friberg LE CPT Pharmacometrics Syst Pharmacol 2014[Oct]; 3 (10): e143- PMID25353186show ga The Markovian approach has been proposed to model American College of Rheumatology's (ACR) response (ACR20, ACR50, or ACR70) reported in rheumatoid arthritis clinical trials to account for the dependency of the scores over time. However, dichotomizing the composite ACR assessment discards much information. Here, we propose a new approach for modeling together the three thresholds: a continuous-time Markov exposure?response model was developed, based on data from five placebo-controlled certolizumab pegol clinical trials. This approach allows adequate prediction of individual ACR20/50/70 time-response, even for non-periodic observations. An exposure?response was established over a large range of licensed and unlicensed doses including phase II dose-ranging data. Simulations from the model (50?400?mg every other week) illustrated the range and sustainability of response (ACR20: 56?68%, ACR50: 27?42%, ACR70: 11?22% at week 24) with maximum clinical effect achieved at the recommended maintenance dose of 200?mg every other week. äSimultaneous Exposure?Response Modeling of ACR20, ACR50, and ACR70 Imp(epmc).pdf DeepDyve Pubget Overpricing