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10.3892/ol.2015.3135 http://scihub22266oqcxt.onion/10.3892/ol.2015.3135 C4473703!4473703!26137168     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Oncol+Lett 2015 ; 9 (6): 2905-9 Nephropedia Template TP {{tp|p=26137168|t=2015. Doxorubicin activates the Notch signaling pathway in osteosarcoma |pdf=|usr=}}{{26137168}} gab.com Text Doxorubicin activates the Notch signaling pathway in osteosarcoma JO: Oncol Lett http://www.kidney.de/pget.php?&tw=1&pmid=26137168 #FOAvip Notch signaling is critical in various biological processes, including cell proliferation, differentiation and apoptosis. Furthermore, accumulating evidence indicated that aberrant Notch signaling has a tumor-promoting function in osteosarcoma. However, the effect of the conventional chemotherapeutic agent, doxorubicin, on Notch signaling remains unclear. In the present study, osteosarcoma cells were treated with various concentrations of doxorubicin and the effect on Notch signaling was analyzed. A cytostatic dose of doxorubicin (<0.5 µM) was identified to significantly activate the Notch signaling pathway in a dose-dependent manner (P<0.01), as demonstrated by the elevated expression levels of Notch target genes. However, a toxic dose of doxorubicin (?0.5 µM) significantly inhibited the Notch signaling pathway (P<0.01). These results indicated a significant correlation between doxorubicin administration and the Notch signaling pathway. Therefore, the present study supports further investigation into Notch and osteosarcoma chemoresistance. Twit Text FOAVip Doxorubicin activates the Notch signaling pathway in osteosarcoma ????Oncol Lett http://www.kidney.de/pget.php?&tw=1&pmid=26137168 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26137168 #FOAvip English Wikipedia <ref>{{Cite pmid|26137168}}</ref> Doxorubicin activates the Notch signaling pathway in osteosarcoma #MMPMID26137168 MEI H; YU L; JI P; YANG J; FANG S; GUO W; LIU Y; CHEN X Oncol Lett 2015[Jun]; 9 (6): 2905-9 PMID26137168show ga Notch signaling is critical in various biological processes, including cell proliferation, differentiation and apoptosis. Furthermore, accumulating evidence indicated that aberrant Notch signaling has a tumor-promoting function in osteosarcoma. However, the effect of the conventional chemotherapeutic agent, doxorubicin, on Notch signaling remains unclear. In the present study, osteosarcoma cells were treated with various concentrations of doxorubicin and the effect on Notch signaling was analyzed. A cytostatic dose of doxorubicin (<0.5 µM) was identified to significantly activate the Notch signaling pathway in a dose-dependent manner (P<0.01), as demonstrated by the elevated expression levels of Notch target genes. However, a toxic dose of doxorubicin (?0.5 µM) significantly inhibited the Notch signaling pathway (P<0.01). These results indicated a significant correlation between doxorubicin administration and the Notch signaling pathway. Therefore, the present study supports further investigation into Notch and osteosarcoma chemoresistance. äDoxorubicin activates the Notch signaling pathway in osteosarcoma (epmc).pdf DeepDyve Pubget Overpricing