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10.1038/srep11525 http://scihub22266oqcxt.onion/10.1038/srep11525 C4473605!4473605!26089239     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Rep 2015 ; 5 (ä): ä Nephropedia Template TP {{tp|p=26089239|t=2015. Human longevity is characterised by high thyroid stimulating hormone secretion without altered energy metabolism |pdf=|usr=}}{{26089239}} gab.com Text Human longevity is characterised by high thyroid stimulating hormone secretion without altered energy metabolism JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=26089239 #FOAvip Few studies have included subjects with the propensity to reach old age in good health, with the aim to disentangle mechanisms contributing to staying healthier for longer. The hypothalamic-pituitary-thyroid (HPT) axis maintains circulating levels of thyroid stimulating hormone (TSH) and thyroid hormone (TH) in an inverse relationship. Greater longevity has been associated with higher TSH and lower TH levels, but mechanisms underlying TSH/TH differences and longevity remain unknown. The HPT axis plays a pivotal role in growth, development and energy metabolism. We report that offspring of nonagenarians with at least one nonagenarian sibling have increased TSH secretion but similar bioactivity of TSH and similar TH levels compared to controls. Healthy offspring and spousal controls had similar resting metabolic rate and core body temperature. We propose that pleiotropic effects of the HPT axis may favour longevity without altering energy metabolism. Twit Text FOAVip Human longevity is characterised by high thyroid stimulating hormone secretion without altered energy metabolism ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=26089239 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26089239 #FOAvip English Wikipedia <ref>{{Cite pmid|26089239}}</ref> Human longevity is characterised by high thyroid stimulating hormone secretion without altered energy metabolism #MMPMID26089239 Jansen SW; Akintola AA; Roelfsema F; van der Spoel E; Cobbaert CM; Ballieux BE; Egri P; Kvarta-Papp Z; Gereben B; Fekete C; Slagboom PE; van der Grond J; Demeneix BA; Pijl H; Westendorp RGJ; van Heemst D Sci Rep 2015[]; 5 (ä): ä PMID26089239show ga Few studies have included subjects with the propensity to reach old age in good health, with the aim to disentangle mechanisms contributing to staying healthier for longer. The hypothalamic-pituitary-thyroid (HPT) axis maintains circulating levels of thyroid stimulating hormone (TSH) and thyroid hormone (TH) in an inverse relationship. Greater longevity has been associated with higher TSH and lower TH levels, but mechanisms underlying TSH/TH differences and longevity remain unknown. The HPT axis plays a pivotal role in growth, development and energy metabolism. We report that offspring of nonagenarians with at least one nonagenarian sibling have increased TSH secretion but similar bioactivity of TSH and similar TH levels compared to controls. Healthy offspring and spousal controls had similar resting metabolic rate and core body temperature. We propose that pleiotropic effects of the HPT axis may favour longevity without altering energy metabolism. äHuman longevity is characterised by high thyroid stimulating hormone s(epmc).pdf DeepDyve Pubget Overpricing