Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26101712
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Am+J+Cancer+Res
2015 ; 5
(4
): 1484-95
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
S100A14, a mediator of epithelial-mesenchymal transition, regulates
proliferation, migration and invasion of human cervical cancer cells
#MMPMID26101712
Wang X
; Yang J
; Qian J
; Liu Z
; Chen H
; Cui Z
Am J Cancer Res
2015[]; 5
(4
): 1484-95
PMID26101712
show ga
S100A14 is an EF-hand calcium-binding protein that has been reported to exert its
biological effects on different types of cells. However, the potential clinical
significance and biological functions of S100A14 in cervical cancer has not yet
been clarified. In this study, we firstly examined the correlation between
S100A14 expression and clinical-pathological parameters in cervical cancers.
Next, we observed the effect of S100A14 on cell cycle progression, cell
proliferation, migration and invasion by employing lentiviral-mediated
overexpression and knockdown of S100A14 in cervical cancer cells. Furthermore, we
investigated the underlying mechanism of S100A14 affecting cell migration and
invasion. Immunohistochemistry analysis demonstrated that S100A14 expression was
associated with the International Federation of Gynecology and Obstetrics (FIGO)
stage (P = 0.025) and lymph node (LN) metastasis (P = 0.001). Functional assays
showed that S100A14 overexpression increased the proportion of G2/M phase,
promoted cell proliferation, migration, and invasion, whereas S100A14 knockdown
exhibited adverse effect on above properties. Mechanistic investigation
demonstrated that S100A14 can act as a mediator of epithelial-mesenchymal
transition (EMT). And overexpression of S100A14 increased expression of
N-cadherin and Vimentin while decreased expression of E-cadherin. The opposite
results were observed in S100A14-silenced cells. Taken together, our data
indicate that S100A14 has a crucial role in cervical cancer progression. This
study significantly increases our understanding of S100A14 functional roles in
cervical cancer, which may lead to the development of a novel therapeutic target
for cervical cancer.
free
free
free
