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http://scihub22266oqcxt.onion/ C4473320!4473320!26101707     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26101707&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Am+J+Cancer+Res 2015 ; 5 (4): 1423-34 Nephropedia Template TP {{tp|p=26101707|t=2015. Metformin inhibits gastric cancer via the inhibition of HIF1?/PKM2 signaling |pdf=|usr=}}{{26101707}} gab.com Text Metformin inhibits gastric cancer via the inhibition of HIF1 /PKM2 signaling JO: Am J Cancer Res http://www.kidney.de/pget.php?&tw=1&pmid=26101707 #FOAvip Recent evidence suggests that anti-diabetic drug metformin prevents cancer progression, but the mechanism by which metformin inhibits tumor growth remains elusive. In this study, we investigated the anticancer role of metformin in gastric cancer and explored the underlying mechanism. The expression of hypoxia inducible factor 1? (HIF1?) and pyruvate kinase M2 (PKM2) in different stages of gastric cancer tissues was detected by immunohistochemistry. Gastric cancer cell viability was evaluated by CCK-8 assay; apoptosis and cell cycle were analyzed by flow cytometry. The expression of PI3K, Akt, HIF1?, PARP, PKM2 and COX in gastric cancer cells was detected by immunofluorescence and Western blot analysis. We found that HIF1? and PKM2 protein expression levels were higher in advanced gastric cancer tissues than in gastritis tissues. Metformin reduced gastric cancer cell viability, invasion and migration. Metformin induced apoptosis and cell cycle arrest in part through inhibiting PARP expression. Metformin downregulated PI3K, Akt, HIF1?, PARP, PKM2 and COX expression. Moreover, overexpression of HIF1? increased gastric cancer cell viability, invasion and migration. In summary, metformin has profound antitumor effect for gastric cancer by inducing intrinsic apoptosis via the inhibition of HIF1?/PKM2 signaling pathway. Twit Text FOAVip Metformin inhibits gastric cancer via the inhibition of HIF1 /PKM2 signaling ????Am J Cancer Res http://www.kidney.de/pget.php?&tw=1&pmid=26101707 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26101707 #FOAvip English Wikipedia <ref>{{Cite pmid|26101707}}</ref> Metformin inhibits gastric cancer via the inhibition of HIF1?/PKM2 signaling #MMPMID26101707 Chen G; Feng W; Zhang S; Bian K; Yang Y; Fang C; Chen M; Yang J; Zou X Am J Cancer Res 2015[]; 5 (4): 1423-34 PMID26101707show ga Recent evidence suggests that anti-diabetic drug metformin prevents cancer progression, but the mechanism by which metformin inhibits tumor growth remains elusive. In this study, we investigated the anticancer role of metformin in gastric cancer and explored the underlying mechanism. The expression of hypoxia inducible factor 1? (HIF1?) and pyruvate kinase M2 (PKM2) in different stages of gastric cancer tissues was detected by immunohistochemistry. Gastric cancer cell viability was evaluated by CCK-8 assay; apoptosis and cell cycle were analyzed by flow cytometry. The expression of PI3K, Akt, HIF1?, PARP, PKM2 and COX in gastric cancer cells was detected by immunofluorescence and Western blot analysis. We found that HIF1? and PKM2 protein expression levels were higher in advanced gastric cancer tissues than in gastritis tissues. Metformin reduced gastric cancer cell viability, invasion and migration. Metformin induced apoptosis and cell cycle arrest in part through inhibiting PARP expression. Metformin downregulated PI3K, Akt, HIF1?, PARP, PKM2 and COX expression. Moreover, overexpression of HIF1? increased gastric cancer cell viability, invasion and migration. In summary, metformin has profound antitumor effect for gastric cancer by inducing intrinsic apoptosis via the inhibition of HIF1?/PKM2 signaling pathway. äMetformin inhibits gastric cancer via the inhibition of HIF1?/PKM2 sig(epmc).pdf DeepDyve Pubget Overpricing