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http://scihub22266oqcxt.onion/ C4473318!4473318!26101705     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26101705&cmd=llinks): Failed to open stream: HTTP request failed! 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Netrin-1 promotes cell migration and invasion by down-regulation of BVES expression in human hepatocellular carcinoma |pdf=|usr=}}{{26101705}} gab.com Text Netrin-1 promotes cell migration and invasion by down-regulation of BVES expression in human hepatocellular carcinoma JO: Am J Cancer Res http://www.kidney.de/pget.php?&tw=1&pmid=26101705 #FOAvip The axon guidance cues netrin-1 has been reported to be associated with cancer progression in various types of human cancers. However, the underlying molecular mechanism of netrin-1-mediated metastasis remains obscure. In this study, we found that overexpression of netrin-1 promoted HCC cell migration and invasion as determined by transwell assay and 3D cell culture assay. However, netrin-1 knockdown inhibited these processes. Further investigation indicated that netrin-1 decreased the expression of Blood Vessel Epicardial Substance (BVES), which was down-regulated in HCC. Interestingly, LY294002, a special inhibitor to PI3K/AKT signaling which was determined as a downstream pathway of netrin-1, restored the reduction in BVES caused by netrin-1. In addition, BVES exhibited an opposite effect on HCC cell metastasis to that of netrin-1. Importantly, up-regulating BVES expression significantly attenuated netrin-1-enhanced migration and invasion, whereas silencing BVES expression rescued the metastatic phenotype in netrin-1 knockdown cells. Moreover, netrin-1 expression was negatively correlated with BVES in HCC tissues and cell lines with different metastatic potential. Taken together, these results reveal that netrin-1 promotes HCC cell metastasis by regulating BVES expression via AKT activation. Twit Text FOAVip Netrin-1 promotes cell migration and invasion by down-regulation of BVES expression in human hepatocellular carcinoma ????Am J Cancer Res http://www.kidney.de/pget.php?&tw=1&pmid=26101705 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26101705 #FOAvip English Wikipedia <ref>{{Cite pmid|26101705}}</ref> Netrin-1 promotes cell migration and invasion by down-regulation of BVES expression in human hepatocellular carcinoma #MMPMID26101705 Han P; Fu Y; Liu J; Wang Y; He J; Gong J; Li M; Tan Q; Li D; Luo Y; Han J; Liu J; Tu W; Wang Y; Tian D; Yan W Am J Cancer Res 2015[]; 5 (4): 1396-409 PMID26101705show ga The axon guidance cues netrin-1 has been reported to be associated with cancer progression in various types of human cancers. However, the underlying molecular mechanism of netrin-1-mediated metastasis remains obscure. In this study, we found that overexpression of netrin-1 promoted HCC cell migration and invasion as determined by transwell assay and 3D cell culture assay. However, netrin-1 knockdown inhibited these processes. Further investigation indicated that netrin-1 decreased the expression of Blood Vessel Epicardial Substance (BVES), which was down-regulated in HCC. Interestingly, LY294002, a special inhibitor to PI3K/AKT signaling which was determined as a downstream pathway of netrin-1, restored the reduction in BVES caused by netrin-1. In addition, BVES exhibited an opposite effect on HCC cell metastasis to that of netrin-1. Importantly, up-regulating BVES expression significantly attenuated netrin-1-enhanced migration and invasion, whereas silencing BVES expression rescued the metastatic phenotype in netrin-1 knockdown cells. Moreover, netrin-1 expression was negatively correlated with BVES in HCC tissues and cell lines with different metastatic potential. Taken together, these results reveal that netrin-1 promotes HCC cell metastasis by regulating BVES expression via AKT activation. äNetrin-1 promotes cell migration and invasion by down-regulation of BV(epmc).pdf DeepDyve Pubget Overpricing