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10.1182/blood-2015-01-621474

http://scihub22266oqcxt.onion/10.1182/blood-2015-01-621474
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C4473118!4473118!25940712
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suck abstract from ncbi


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pmid25940712      Blood 2015 ; 125 (25): 3905-16
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  • Tumor indoleamine 2,3-dioxygenase (IDO) inhibits CD19-CAR T cells and is downregulated by lymphodepleting drugs #MMPMID25940712
  • Ninomiya S; Narala N; Huye L; Yagyu S; Savoldo B; Dotti G; Heslop HE; Brenner MK; Rooney CM; Ramos CA
  • Blood 2015[Jun]; 125 (25): 3905-16 PMID25940712show ga
  • Tumor IDO inhibits CD19-CART activity, likely via induction of the kynurenine pathway, whose metabolites directly inhibit T cells.Fludarabine and cyclophosphamide, frequently used before CART administration, downregulate IDO expression in lymphoma cells.
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