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10.4049/jimmunol.1402826 http://scihub22266oqcxt.onion/10.4049/jimmunol.1402826 C4472942!4472942 !26002976     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26002976 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Immunol 2015 ; 195 (1 ): 265-76 Nephropedia Template TP {{tp|p=26002976 |t=2015. Dominant Suppression of Inflammation via Targeted Mutation of the mRNA Destabilizing Protein Tristetraprolin |pdf=|usr=}}{{26002976 }} gab.com Text Dominant Suppression of Inflammation via Targeted Mutation of the mRNA Destabilizing Protein Tristetraprolin JO: J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=26002976 #FOAvip In myeloid cells, the mRNA-destabilizing protein tristetraprolin (TTP) is induced and extensively phosphorylated in response to LPS. To investigate the role of two specific phosphorylations, at serines 52 and 178, we created a mouse strain in which those residues were replaced by nonphosphorylatable alanine residues. The mutant form of TTP was constitutively degraded by the proteasome and therefore expressed at low levels, yet it functioned as a potent mRNA destabilizing factor and inhibitor of the expression of many inflammatory mediators. Mice expressing only the mutant form of TTP were healthy and fertile, and their systemic inflammatory responses to LPS were strongly attenuated. Adaptive immune responses and protection against infection by Salmonella typhimurium were spared. A single allele encoding the mutant form of TTP was sufficient for enhanced mRNA degradation and underexpression of inflammatory mediators. Therefore, the equilibrium between unphosphorylated and phosphorylated TTP is a critical determinant of the inflammatory response, and manipulation of this equilibrium may be a means of treating inflammatory pathologies. Twit Text FOAVip Dominant Suppression of Inflammation via Targeted Mutation of the mRNA Destabilizing Protein Tristetraprolin ????J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=26002976 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26002976 #FOAvip English Wikipedia <ref>{{Cite pmid|26002976 }}</ref> Dominant Suppression of Inflammation via Targeted Mutation of the mRNA Destabilizing Protein Tristetraprolin #MMPMID26002976 Ross EA ; Smallie T ; Ding Q ; O'Neil JD ; Cunliffe HE ; Tang T ; Rosner DR ; Klevernic I ; Morrice NA ; Monaco C ; Cunningham AF ; Buckley CD ; Saklatvala J ; Dean JL ; Clark AR J Immunol 2015[Jul]; 195 (1 ): 265-76 PMID26002976 show ga In myeloid cells, the mRNA-destabilizing protein tristetraprolin (TTP) is induced and extensively phosphorylated in response to LPS. To investigate the role of two specific phosphorylations, at serines 52 and 178, we created a mouse strain in which those residues were replaced by nonphosphorylatable alanine residues. The mutant form of TTP was constitutively degraded by the proteasome and therefore expressed at low levels, yet it functioned as a potent mRNA destabilizing factor and inhibitor of the expression of many inflammatory mediators. Mice expressing only the mutant form of TTP were healthy and fertile, and their systemic inflammatory responses to LPS were strongly attenuated. Adaptive immune responses and protection against infection by Salmonella typhimurium were spared. A single allele encoding the mutant form of TTP was sufficient for enhanced mRNA degradation and underexpression of inflammatory mediators. Therefore, the equilibrium between unphosphorylated and phosphorylated TTP is a critical determinant of the inflammatory response, and manipulation of this equilibrium may be a means of treating inflammatory pathologies. |*Mutation [MESH] |Alanine/genetics/metabolism [MESH] |Amino Acid Substitution [MESH] |Animals [MESH] |Cell Line [MESH] |Cytokines/antagonists & inhibitors/genetics/immunology [MESH] |Female [MESH] |Gene Expression [MESH] |Inflammation/genetics/immunology/pathology [MESH] |Lipopolysaccharides/pharmacology [MESH] |Macrophages/drug effects/*immunology/pathology [MESH] |Male [MESH] |Mice [MESH] |Mice, Inbred C57BL [MESH] |Phosphoproteins/genetics/immunology [MESH] |Phosphorylation [MESH] |Primary Cell Culture [MESH] |RNA Stability [MESH] |RNA, Messenger/genetics/*immunology [MESH] |Recombinant Fusion Proteins/genetics/immunology [MESH] |Salmonella Infections, Animal/genetics/*immunology/pathology [MESH] |Salmonella typhimurium/immunology [MESH] |Serine/genetics/metabolism [MESH]Dominant Suppression of Inflammation via Targeted Mutation of the mRNA(epmc).pdf DeepDyve Pubget Overpricing