Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1016/j.bmcl.2011.12.044 http://scihub22266oqcxt.onion/10.1016/j.bmcl.2011.12.044 C4472446!4472446!22212721     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Bioorg+Med+Chem+Lett 2012 ; 22 (2): 876-80 Nephropedia Template TP {{tp|p=22212721|t=2012. Biological evaluation and docking studies of recently identified inhibitors of phosphoinositide-3-kinases |pdf=|usr=}}{{22212721}} gab.com Text Biological evaluation and docking studies of recently identified inhibitors of phosphoinositide-3-kinases JO: Bioorg Med Chem Lett http://www.kidney.de/pget.php?&tw=1&pmid=22212721 #FOAvip The alpha isoform of the phosphatidylinositol-3-kinases (PI3K?) is often mutated, amplified and overex-pressed in human tumors. In an effort to develop new inhibitors targeting this enzyme, we carried out a pharmacophore model study based on six PI3K?-selective compounds. The pharmacophore searching identified three structurally novel inhibitors of PI3K? and its H1047R mutant. Our biological studies show that two of our hit molecules suppressed the formation of pAKT, a downstream effector of PI3K?, and induced apoptosis in the HCT116 colon cancer cell line. QPLD-based docking showed that residues Asp933, Glu849, Val851, and Gln859 appeared to be key binding residues for active inhibitors. Twit Text FOAVip Biological evaluation and docking studies of recently identified inhibitors of phosphoinositide-3-kinases ????Bioorg Med Chem Lett http://www.kidney.de/pget.php?&tw=1&pmid=22212721 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=22212721 #FOAvip English Wikipedia <ref>{{Cite pmid|22212721}}</ref> Biological evaluation and docking studies of recently identified inhibitors of phosphoinositide-3-kinases #MMPMID22212721 Sabbah DA; Simms NA; Brattain MG; Vennerstrom JL; Zhong H Bioorg Med Chem Lett 2012[Jan]; 22 (2): 876-80 PMID22212721show ga The alpha isoform of the phosphatidylinositol-3-kinases (PI3K?) is often mutated, amplified and overex-pressed in human tumors. In an effort to develop new inhibitors targeting this enzyme, we carried out a pharmacophore model study based on six PI3K?-selective compounds. The pharmacophore searching identified three structurally novel inhibitors of PI3K? and its H1047R mutant. Our biological studies show that two of our hit molecules suppressed the formation of pAKT, a downstream effector of PI3K?, and induced apoptosis in the HCT116 colon cancer cell line. QPLD-based docking showed that residues Asp933, Glu849, Val851, and Gln859 appeared to be key binding residues for active inhibitors. äBiological evaluation and docking studies of recently identified inhib(epmc).pdf DeepDyve Pubget Overpricing