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10.1146/annurev.genom.9.081307.164217 http://scihub22266oqcxt.onion/10.1146/annurev.genom.9.081307.164217 C4472309!4472309!19715442     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Annu+Rev+Genomics+Hum+Genet 2009 ; 10 (ä): 451-81 Nephropedia Template TP {{tp|p=19715442|t=2009. Copy Number Variation in Human Health, Disease, and Evolution |pdf=|usr=}}{{19715442}} gab.com Text Copy Number Variation in Human Health, Disease, and Evolution JO: Annu Rev Genomics Hum Genet http://www.kidney.de/pget.php?&tw=1&pmid=19715442 #FOAvip Copy number variation (CNV) is a source of genetic diversity in humans. Numerous CNVs are being identified with various genome analysis platforms, including array comparative genomic hybridization (aCGH), single nucleotide polymorphism (SNP) genotyping platforms, and next-generation sequencing. CNV formation occurs by both recombination-based and replication-based mechanisms and de novo locus-specific mutation rates appear much higher for CNVs than for SNPs. By various molecular mechanisms, including gene dosage, gene disruption, gene fusion, position effects, etc., CNVs can cause Mendelian or sporadic traits, or be associated with complex diseases. However, CNV can also represent benign polymorphic variants. CNVs, especially gene duplication and exon shuffling, can be a predominant mechanism driving gene and genome evolution. Twit Text FOAVip Copy Number Variation in Human Health, Disease, and Evolution ????Annu Rev Genomics Hum Genet http://www.kidney.de/pget.php?&tw=1&pmid=19715442 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=19715442 #FOAvip English Wikipedia <ref>{{Cite pmid|19715442}}</ref> Copy Number Variation in Human Health, Disease, and Evolution #MMPMID19715442 Zhang F; Gu W; Hurles ME; Lupski JR Annu Rev Genomics Hum Genet 2009[]; 10 (ä): 451-81 PMID19715442show ga Copy number variation (CNV) is a source of genetic diversity in humans. Numerous CNVs are being identified with various genome analysis platforms, including array comparative genomic hybridization (aCGH), single nucleotide polymorphism (SNP) genotyping platforms, and next-generation sequencing. CNV formation occurs by both recombination-based and replication-based mechanisms and de novo locus-specific mutation rates appear much higher for CNVs than for SNPs. By various molecular mechanisms, including gene dosage, gene disruption, gene fusion, position effects, etc., CNVs can cause Mendelian or sporadic traits, or be associated with complex diseases. However, CNV can also represent benign polymorphic variants. CNVs, especially gene duplication and exon shuffling, can be a predominant mechanism driving gene and genome evolution. äCopy Number Variation in Human Health, Disease, and Evolution (epmc).pdf DeepDyve Pubget Overpricing