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10.1016/j.bpj.2015.05.011 http://scihub22266oqcxt.onion/10.1016/j.bpj.2015.05.011 C4472221!4472221 !26083921     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26083921 &cmd=llinks): Failed to open stream: HTTP request failed! 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Orientation and Order of the Amide Group of Sphingomyelin in Bilayers Determined by Solid-State NMR |pdf=|usr=}}{{26083921 }} gab.com Text Orientation and Order of the Amide Group of Sphingomyelin in Bilayers Determined by Solid-State NMR JO: Biophys J http://www.kidney.de/pget.php?&tw=1&pmid=26083921 #FOAvip Sphingomyelin (SM) and cholesterol (Chol) are considered essential for the formation of lipid rafts; however, the types of molecular interactions involved in this process, such as intermolecular hydrogen bonding, are not well understood. Since, unlike other phospholipids, SM is characterized by the presence of an amide group, it is essential to determine the orientation of the amide and its order in the lipid bilayers to understand the nature of the hydrogen bonds in lipid rafts. For this study, 1'-(13)C-2-(15)N-labeled and 2'-(13)C-2-(15)N-labeled SMs were prepared, and the rotational-axis direction and order parameters of the SM amide in bilayers were determined based on (13)C and (15)N chemical-shift anisotropies and intramolecular (13)C-(15)N dipole coupling constants. Results revealed that the amide orientation was minimally affected by Chol, whereas the order was enhanced significantly in its presence. Thus, Chol likely promotes the formation of an intermolecular hydrogen-bond network involving the SM amide without significantly changing its orientation, providing a higher order to the SM amide. To our knowledge, this study offers new insight into the significance of the SM amide orientation with regard to molecular recognition in lipid rafts, and therefore provides a deeper understanding of the mechanism of their formation. Twit Text FOAVip Orientation and Order of the Amide Group of Sphingomyelin in Bilayers Determined by Solid-State NMR ????Biophys J http://www.kidney.de/pget.php?&tw=1&pmid=26083921 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26083921 #FOAvip English Wikipedia <ref>{{Cite pmid|26083921 }}</ref> Orientation and Order of the Amide Group of Sphingomyelin in Bilayers Determined by Solid-State NMR #MMPMID26083921 Matsumori N ; Yamaguchi T ; Maeta Y ; Murata M Biophys J 2015[Jun]; 108 (12 ): 2816-24 PMID26083921 show ga Sphingomyelin (SM) and cholesterol (Chol) are considered essential for the formation of lipid rafts; however, the types of molecular interactions involved in this process, such as intermolecular hydrogen bonding, are not well understood. Since, unlike other phospholipids, SM is characterized by the presence of an amide group, it is essential to determine the orientation of the amide and its order in the lipid bilayers to understand the nature of the hydrogen bonds in lipid rafts. For this study, 1'-(13)C-2-(15)N-labeled and 2'-(13)C-2-(15)N-labeled SMs were prepared, and the rotational-axis direction and order parameters of the SM amide in bilayers were determined based on (13)C and (15)N chemical-shift anisotropies and intramolecular (13)C-(15)N dipole coupling constants. Results revealed that the amide orientation was minimally affected by Chol, whereas the order was enhanced significantly in its presence. Thus, Chol likely promotes the formation of an intermolecular hydrogen-bond network involving the SM amide without significantly changing its orientation, providing a higher order to the SM amide. To our knowledge, this study offers new insight into the significance of the SM amide orientation with regard to molecular recognition in lipid rafts, and therefore provides a deeper understanding of the mechanism of their formation. |Amides/chemistry [MESH] |Cholesterol/chemistry [MESH] |Lipid Bilayers/*chemistry [MESH]Orientation and Order of the Amide Group of Sphingomyelin in Bilayers (epmc).pdf DeepDyve Pubget Overpricing