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10.1016/j.stemcr.2015.04.007 http://scihub22266oqcxt.onion/10.1016/j.stemcr.2015.04.007 C4472037!4472037!25981413     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Stem+Cell+Reports 2015 ; 4 (6): 1046-60 Nephropedia Template TP {{tp|p=25981413|t=2015. Fibrogenic Cell Plasticity Blunts Tissue Regeneration and Aggravates Muscular Dystrophy |pdf=|usr=}}{{25981413}} gab.com Text Fibrogenic Cell Plasticity Blunts Tissue Regeneration and Aggravates Muscular Dystrophy JO: Stem Cell Reports http://www.kidney.de/pget.php?&tw=1&pmid=25981413 #FOAvip Preservation of cell identity is necessary for homeostasis of most adult tissues. This process is challenged every time a tissue undergoes regeneration after stress or injury. In the lethal Duchenne muscular dystrophy (DMD), skeletal muscle regenerative capacity declines gradually as fibrosis increases. Using genetically engineered tracing mice, we demonstrate that, in dystrophic muscle, specialized cells of muscular, endothelial, and hematopoietic origins gain plasticity toward a fibrogenic fate via a TGF?-mediated pathway. This results in loss of cellular identity and normal function, with deleterious consequences for regeneration. Furthermore, this fibrogenic process involves acquisition of a mesenchymal progenitor multipotent status, illustrating a link between fibrogenesis and gain of progenitor cell functions. As this plasticity also was observed in DMD patients, we propose that mesenchymal transitions impair regeneration and worsen diseases with a fibrotic component. Twit Text FOAVip Fibrogenic Cell Plasticity Blunts Tissue Regeneration and Aggravates Muscular Dystrophy ????Stem Cell Reports http://www.kidney.de/pget.php?&tw=1&pmid=25981413 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25981413 #FOAvip English Wikipedia <ref>{{Cite pmid|25981413}}</ref> Fibrogenic Cell Plasticity Blunts Tissue Regeneration and Aggravates Muscular Dystrophy #MMPMID25981413 Pessina P; Kharraz Y; Jardí M; Fukada Si; Serrano A; Perdiguero E; Muñoz-Cánoves P Stem Cell Reports 2015[Jun]; 4 (6): 1046-60 PMID25981413show ga Preservation of cell identity is necessary for homeostasis of most adult tissues. This process is challenged every time a tissue undergoes regeneration after stress or injury. In the lethal Duchenne muscular dystrophy (DMD), skeletal muscle regenerative capacity declines gradually as fibrosis increases. Using genetically engineered tracing mice, we demonstrate that, in dystrophic muscle, specialized cells of muscular, endothelial, and hematopoietic origins gain plasticity toward a fibrogenic fate via a TGF?-mediated pathway. This results in loss of cellular identity and normal function, with deleterious consequences for regeneration. Furthermore, this fibrogenic process involves acquisition of a mesenchymal progenitor multipotent status, illustrating a link between fibrogenesis and gain of progenitor cell functions. As this plasticity also was observed in DMD patients, we propose that mesenchymal transitions impair regeneration and worsen diseases with a fibrotic component. äFibrogenic Cell Plasticity Blunts Tissue Regeneration and Aggravates M(epmc).pdf DeepDyve Pubget Overpricing